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The Effect of Graded Doses of Secretin on Serum Trypsin, Serum Pancreatic Amylase, Serum Insulin, Plasma Somatostatin, and Plasma Pancreatic Polypeptide in Man

1984; Taylor & Francis; Volume: 19; Issue: 1 Linguagem: Inglês

10.1080/00365521.1984.12005678

1502-7708

Jon Florholmen, P. G. Burhol, Rolf Jorde, Helge L. Waldum,

Pancreatic function and diabetes

Six healthy men were studied with intravenous infusions of 0.3. 1.0, and 3.0 CU/kg-h of pure porcine secretin on separate days. The secretin elimination followed a first-order kinetics. Low pharmacological doses of secretin had no significant effects on blood levels of trypsin, pancreatic amylase, insulin, somatostatin, or pancreatic polypeptide (PP). whereas high pharmacological doses significantly elevated the blood levels of trypsin, pancreatic amylase, insulin, and somatostatin but were without effect on PP.