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Impaired Immune Response by Isoniazid Treatment During Intravesical BCG Administration in the Guinea Pig

1992; Lippincott Williams & Wilkins; Volume: 148; Issue: 5 Part 1 Linguagem: Inglês

10.1016/s0022-5347(17)36973-2

1527-3792

Liesbeth C. De Boer, Peter A. Steerenberg, A.P.M. van der Meijden, B. van Klingeren, Wim H. de Jong, Anneke Elgersma, F.M.J. Debruyne, E. J. Ruitenberg,

Urinary Tract Infections Management

No AccessJournal of Urology1 Nov 1992Impaired Immune Response by Isoniazid Treatment During Intravesical BCG Administration in the Guinea Pig Liesbeth C. De Boer, Peter A. Steerenberg, Ad P.M. Van Der Meijden, Bert Van Klingeren, Wim H. De Jong, Anneke Elgersma, Frans M.J. Debruyne, and E. Joost Ruitenberg Liesbeth C. De BoerLiesbeth C. De Boer More articles by this author , Peter A. SteerenbergPeter A. Steerenberg More articles by this author , Ad P.M. Van Der MeijdenAd P.M. Van Der Meijden More articles by this author , Bert Van KlingerenBert Van Klingeren More articles by this author , Wim H. De JongWim H. De Jong More articles by this author , Anneke ElgersmaAnneke Elgersma More articles by this author , Frans M.J. DebruyneFrans M.J. Debruyne More articles by this author , and E. Joost RuitenbergE. Joost Ruitenberg More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)36973-2AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail At present, isoniazid (INH) is being used prophylactically to reduce the side effects of intravesical BCG therapy for superficial bladder cancer, although it is not clear whether or not this reduces the antitumor efficacy of BCG. In this study the impact of INH treatment on the immune response after repeated intravesical BCG administration was investigated in guinea pigs. INH was given on the 3 days around each BCG instillation. We found that the administration of INH severely impaired the immunological effects of BCG. The induction of mononuclear cell infiltration in the bladder wall was reduced. Enlargement of the regional lymph nodes (weight and number of cells), and increase of MHC Class II expression on the lymph node cells, normally observed after intravesical BCG administration, were inhibited by INH. Systemic immunity, measured by the DTH reaction in the skin to PPD, was also diminished due to the combined treatment of BCG with INH. When INH was administered during the last 4 of 6 BCG instillations, the immune response to BCG was still impaired. A five-fold increase of the dose of BCG did not overcome the effect of INH. INH probably did not exert a direct suppression of the immune system of the guinea pig as the DNCB skin reactivity was not influenced. Although INH concentrations in the urine were high at the onset of the instillation, in vitro experiments indicated that the effect of INH may not be caused by killing of the BCG organisms shortly after application in the bladder. In conclusion, our data in guinea pigs suggest that the use of INH may impair the immune response to intravesical BCG. As this response may be important for the antitumor effect of BCG, urologists should be cautious with the prophylactic use of INH. The influence on the antitumor efficacy is now investigated in man. © 1992 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited ByDUREK C, RÜSCH-GERDES S, JOCHAM D and BÖHLE A (2018) INTERFERENCE OF MODERN ANTIBACTERIALS WITH BACILLUS CALMETTE-GUERIN VIABILITYJournal of Urology, VOL. 162, NO. 6, (1959-1962), Online publication date: 1-Dec-1999.Vegt P, van der Meijden A, Sylvester R, Brausi M, Holtl W and de Balincourt C (2018) Does Isoniazid Reduce Side Effects of Intravesical Bacillus Calmette-Guerin Therapy in Superficial Bladder Cancer? Interim Results of European Organization for Research and Treatment of Cancer Protocol 30911Journal of Urology, VOL. 157, NO. 4, (1246-1249), Online publication date: 1-Apr-1997.Böhle A, Thanhäuser A, Ulmer A, Ernst M, Flad H and Jocham D (2018) Dissecting the Immunobiological Effects of Bacillus Calmette-Guérin (BCG) In Vitro: Evidence of a Distinct BCG-Activated Killer (BAK) Cell PhenomenonJournal of Urology, VOL. 150, NO. 6, (1932-1937), Online publication date: 1-Dec-1993. Volume 148Issue 5 Part 1November 1992Page: 1577-1582 Advertisement Copyright & Permissions© 1992 by The American Urological Association Education and Research, Inc.KeywordsBacillus Calmette-Guérinisoniazidbladderbladder neoplasmsMetricsAuthor Information Liesbeth C. De Boer More articles by this author Peter A. Steerenberg More articles by this author Ad P.M. Van Der Meijden More articles by this author Bert Van Klingeren More articles by this author Wim H. De Jong More articles by this author Anneke Elgersma More articles by this author Frans M.J. Debruyne More articles by this author E. Joost Ruitenberg More articles by this author Expand All Advertisement PDF DownloadLoading ...