Rajani B, Smith TA, Reith JD, Goldblum JR: Retroperitoneal Leiomyosarcomas Unassociated with the Gastrointestinal Tract: A Clinicopathologic Analysis of 17 Cases. Mod Pathol 1999;12:21–28.
2000; Elsevier BV; Volume: 13; Issue: 1 Linguagem: Inglês
10.1038/modpathol.3880015
ISSN1530-0285
Autores Tópico(s)Metastasis and carcinoma case studies
ResumoTo the Editor: In the interesting paper describing retroperitoneal leiomyosarcomas, Rajani et al. (1) mentioned repeatedly a concept of extra-gastrointestinal gastrointestinal stromal tumors, which should be differentiated from leiomyosarcomas.However, this concept appears to be questionable from a histogenetic point of view.Gastrointestinal stromal tumors (GIST) originate from interstitial cell of Cajal, i.e., from the gastrointestinal pacemaker cell (more precisely: they differentiate toward this cell), as supported by several studies (2-4).The occurrence of the pacemaker cell in the retroperitoneum or in other extra-gastrointestinal sites was not described until now.Consequently, we do not know the origin of possible extragastrointestinal GIST.One may consider two explanations for this:
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