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Sepsis research: where have we gone wrong?

2006; Elsevier BV; Volume: 8; Issue: 3 Linguagem: Inglês

10.1016/s1441-2772(23)02099-9

2652-9335

John C. Marshall,

Vitamin C and Antioxidants Research

Despite a strong biological rationale and no shortage of potential therapeutic targets, attempts to modulate the host response in sepsis over the past two decades have been profoundly disappointing. Even when efficacy has been demonstrated in clinical trials, the magnitude of benefit is small. The author argues that this results not from any intrinsic impossibility of treating sepsis as a disease, nor a lack of biologically efficacious interventions, but rather from shortcomings in three domains of clinical investigation - conceptual, methodological and organisational. (non-author abstract)