Produção Nacional
Revisado por pares
Increased peripheral vascular resistance in male patients with traumatic lower limb amputation
2015; Lippincott Williams & Wilkins; Volume: 20; Issue: 6 Linguagem: Inglês
10.1097/mbp.0000000000000148
ISSN1473-5725
AutoresMarcelle Paula‐Ribeiro, Marília M.N. Garcia, Daniel Godoy Martinêz, Jorge Roberto Perrout de Lima, Mateus Camaroti Laterza,
Tópico(s)Cardiac Arrest and Resuscitation
ResumoThe increased morbidity and mortality in traumatic lower limb amputees can be explained by the development of risk factors, among which high blood pressure plays an important role. However, the possible mechanisms underlying increased blood pressure levels observed in this population remain unclear. Thus, we aimed to test the hypothesis that peripheral vascular resistance is increased at rest in patients with traumatic lower limb amputation.In a cross-sectional study, eight patients with traumatic unilateral lower limb amputation (amputee group) and eight healthy individuals without amputation (control group) were included. Resting blood pressure, heart rate, and forearm blood flow were recorded simultaneously and thus, forearm vascular resistance was calculated.The amputee group showed higher systolic (126±2 vs. 118±5 mmHg, P<0.01), diastolic (78±2 vs. 63±3 mmHg, P<0.01), mean blood pressure (94±2 vs. 81±3 mmHg, P<0.01), and heart rate (74±5 vs. 65±8 bpm, P=0.02) compared with the control group. Despite the similar forearm blood flow response between groups, patients with traumatic lower limb amputation presented increased peripheral vascular resistance at rest compared with the control group (31.3±3.8 vs. 25.7±6.5 U, P=0.05).Patients with traumatic amputation present increased peripheral vascular resistance. Our findings clarify one possible mechanism underlying the higher blood pressure levels observed in this population.
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