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Nuklearmedizinische Diagnostik der Demenz vom Alzheimer-Typ

2008; Thieme Medical Publishers (Germany); Volume: 113; Issue: 06 Linguagem: Inglês

10.1055/s-2008-1067620

1439-4413

F. Grünwald, Karl Broich, Armin Hartmann, Stéphane Adam, R. Erkwoh, A. Bockisch, Stacey Frede, A. Hotze, K. Reichmann, H. J. Biersack,

Psychiatric care and mental health services

Eleven patients with Alzheimer type dementia were investigated by single-photon-emission computed tomography (SPECT) using 99mTc-hexamethylpropylene-aminoxim (HM-PAO). Nine had a typical, symmetrically reduced enrichment in the parieto-temporo-occipital area. In three of these nine patients a similar pattern was recorded additionally in the frontal, in the remaining two in the temporal or parietal region. In a semi-quantitative evaluation radioactivity concentrations in the cerebrum and cerebellum were compared. It demonstrated that there was in relation to the cerebellum a reduced concentration in seven of the eight studied cerebral regions. The relative blood flow of the parieto-temporo-occipital region was most markedly affected and in patients with Alzheimer type dementia was reduced by 25% below that of normal subjects. The results indicate that cerebral SPECT with HM-PAO is a reasonable method of investigation to confirm the diagnosis of "Alzheimer type dementia" and exclude other cerebral disease, especially if pathognomonic findings are to be obtained.