Potential utility of gonadotropin-releasing hormone agonists in the management of ovarian hyperandrogenism
1990; Elsevier BV; Volume: 53; Issue: 5 Linguagem: Inglês
10.1016/s0015-0282(16)53508-0
ISSN1556-5653
AutoresEdward E. Wallach, Eli Y. Adashi,
Tópico(s)Ovarian cancer diagnosis and treatment
ResumoGonadotropin-releasing hormone agonists are potent suppressors of ovarian androgen biosynthesis even in the face of severe hyperandrogenism (e.g., hyperinsulinemia, hyperthecosis). Gonadotropin-releasing hormone agonists are clinically useful in the context of hirsutism. The use of Gn-RH-a in the context of hirsutism is not duration-limited in that the induced hypoestrogenism and its consequent complications are likely to be effectively managed by the concurrent provision of estrogen replacement therapy.
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