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A Sham Controlled Trial of Transurethral Microwave Therapy with Subsequent Treatment of the Control Group

1994; Lippincott Williams & Wilkins; Volume: 152; Issue: 2 Part 1 Linguagem: Inglês

10.1016/s0022-5347(17)32761-1

1527-3792

A S Bdesha, C Bunce, M. E. SNELL, R. O'N. WITHEROW,

Pelvic floor disorders treatments

No AccessJournal of Urology1 Aug 1994A Sham Controlled Trial of Transurethral Microwave Therapy with Subsequent Treatment of the Control Group A.S. Bdesha, C.J. Bunce, M.E. Snell, and R. O'N. Witherow A.S. BdeshaA.S. Bdesha , C.J. BunceC.J. Bunce , M.E. SnellM.E. Snell , and R. O'N. WitherowR. O'N. Witherow View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)32761-1AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail To investigate whether there is a significant placebo component to the improvements seen after 1-session transurethral microwave treatment, 40 patients with significant symptoms of prostatism and unequivocally benign glands were recruited to take part in a sham controlled study. After an active treatment the mean American Urological Association symptom scores improved by 63% (19.2 to 7.1) while after a sham treatment symptom scores improved only marginally (18.8 to 16.2, p < 0.001). Residual volumes decreased by 50% (104 to 52ml.) and flow rates increased by 2.3ml. per second after an active treatment with no improvement after a sham treatment. There was a consistently greater improvement after an active treatment compared to a sham treatment. Patients who had received a sham treatment were then offered an active treatment and showed improvements similar to those in the original actively treated group and much greater than after the original sham treatment. Mean symptom scores decreased from 16.2 to 9.9 (p < 0.004). Residual volumes decreased from 94 to 40 ml. (p < 0.005) and flow rates increased by 1.6ml. per second, while these same criteria had deteriorated after a sham treatment. Side effects were mild and short lived, with no patients reporting sexual dysfunction as a consequence of treatment. Transurethral microwave therapy is an effective well tolerated treatment for select patients with benign prostatic hypertrophy and the placebo effect of treatment is minimal. © 1994 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited ByRoehrborn C, Gange S, Shore N, Giddens J, Bolton D, Cowan B, Brown B, McVary K, Te A, Gholami S, Rashid P, Moseley W, Chin P, Dowling W, Freedman S, Incze P, Coffield K, Borges F and Rukstalis D (2018) The Prostatic Urethral Lift for the Treatment of Lower Urinary Tract Symptoms Associated with Prostate Enlargement Due to Benign Prostatic Hyperplasia: The L.I.F.T. StudyJournal of Urology, VOL. 190, NO. 6, (2161-2167), Online publication date: 1-Dec-2013.DJAVAN B, ROEHRBORN C, SHARIAT S, GHAWIDEL K and MARBERGER M (2018) PROSPECTIVE RANDOMIZED COMPARISON OF HIGH ENERGY TRANSURETHRAL MICROWAVE THERMOTHERAPY VERSUS alpha-BLOCKER TREATMENT OF PATIENTS WITH BENIGN PROSTATIC HYPERPLASIAJournal of Urology, VOL. 161, NO. 1, (139-143), Online publication date: 1-Jan-1999.DJAVAN B, FAKHARI M, SHARIAT S, GHAWIDEL K and MARBERGER M (2018) A NOVEL INTRAURETHRAL PROSTATIC BRIDGE CATHETER FOR PREVENTION OF TEMPORARY PROSTATIC OBSTRUCTION FOLLOWING HIGH ENERGY TRANSURETHRAL MICROWAVE THERMOTHERAPY IN PATIENTS WITH BENIGN PROSTATIC HYPERPLASIAJournal of Urology, VOL. 161, NO. 1, (144-151), Online publication date: 1-Jan-1999.DJAVAN B, SHARIAT S, SCHAFER B and MARBERGER M (2018) TOLERABILITY OF HIGH ENERGY TRANSURETHRAL MICROWAVE THERMOTHERAPY WITH TOPICAL URETHRAL ANESTHESIA: RESULTS OF A PROSPECTIVE, RANDOMIZED, SINGLE-BLINDED CLINICAL TRIALJournal of Urology, VOL. 160, NO. 3 Part 1, (772-776), Online publication date: 1-Sep-1998.Hallin A and Berlin T (2018) TRANSURETHRAL MICROWAVE THERMOTHERAPY FOR BENIGN PROSTATIC HYPERPLASIA: CLINICAL OUTCOME AFTER 4 YEARSJournal of Urology, VOL. 159, NO. 2, (459-464), Online publication date: 1-Feb-1998.Ramsey E, Miller P and Parsons K (2018) A Novel Transurethral Microwave Thermal Ablation System to Treat Benign Prostatic Hyperplasia: Results of a Prospective Multicenter Clinical TrialJournal of Urology, VOL. 158, NO. 1, (112-119), Online publication date: 1-Jul-1997. Volume 152Issue 2 Part 1August 1994Page: 453-458 Advertisement Copyright & Permissions© 1994 by The American Urological Association Education and Research, Inc.Keywordsprostatic hypertrophyprostatic diseasesmicrowavesMetricsAuthor Information A.S. Bdesha More articles by this author C.J. Bunce More articles by this author M.E. Snell More articles by this author R. O'N. Witherow More articles by this author Expand All Advertisement PDF DownloadLoading ...