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Congenital Unilateral Hydronephrosis in a Rat Model: Continuous Renal Pelvic and Bladder Pressures

1994; Lippincott Williams & Wilkins; Volume: 152; Issue: 2 Part 2 Linguagem: Inglês

10.1016/s0022-5347(17)32674-5

1527-3792

Jan Fichtner, Frank G. Boineau, John E. Lewy, Richard K. Sibley, Richard C. Vari, Linda M. Dairiki Shortliffe,

Kidney Stones and Urolithiasis Treatments

No AccessJournal of UrologyResearch1 Aug 1994Congenital Unilateral Hydronephrosis in a Rat Model: Continuous Renal Pelvic and Bladder Pressures Jan Fichtner, Frank G. Boineau, John E. Lewy, R.K. Sibley, Richard C. Vari, and Linda M.D. Shortliffe Jan FichtnerJan Fichtner More articles by this author , Frank G. BoineauFrank G. Boineau More articles by this author , John E. LewyJohn E. Lewy More articles by this author , R.K. SibleyR.K. Sibley More articles by this author , Richard C. VariRichard C. Vari More articles by this author , and Linda M.D. ShortliffeLinda M.D. Shortliffe More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)32674-5AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail We investigated a rat model with inbred unilateral congenital hydronephrosis. Simultaneous bladder and renal pelvic pressures were measured during different urinary flows, and during bladder filling and voiding in these congenitally hydronephrotic rats (approximately 45 days old) and normal nonhydronephrotic rats from the same colony. Differential pressures between pelvis and proximal ureter were determined. Upon termination of the experiment the urinary tract was removed and processed for histological examination. Hydronephrotic rats had significantly higher renal pelvic pressures throughout bladder filling at all urinary flow rates than normal rats. These elevated renal pelvic pressures exceeded bladder pressures at high flows (for example bladder pressure at 50% capacity was 8.9 ± 3.1cm. water and corresponding pelvic pressure was 20.8 ± 2.1 [hydronephrosis] versus pelvic pressure 7.4 ± 1.1 [control]). While pressures in the proximal ureter were higher than in the pelvis in normal rats the hydronephrotic rats showed significantly higher pressures in the pelvis, suggesting that the site of obstruction is the ureteropelvic junction. Histological evaluation of the excised kidneys revealed only minimal tubular changes. This study represents a unique animal model with unilateral hydronephrosis from a partially obstructing ureteropelvic junction. Moreover, the data indicate that partial urinary obstruction and the associated renal pelvic pressures should be defined with reference to bladder fullness and urinary flow rates. © 1994 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited ByWÅHLIN N, STENBERG A and PERSSON A (2018) RENAL BLOOD FLOW INCREASE DURING VOLUME EXPANSION IN HYDRONEPHROTIC RATSJournal of Urology, VOL. 165, NO. 5, (1696-1699), Online publication date: 1-May-2001.WEN J, CHEN Y, FROKIAER J, JORGENSEN T and DJURHUUS J (2018) EXPERIMENTAL PARTIAL UNILATERAL URETER OBSTRUCTION. I. PRESSURE FLOW RELATIONSHIP IN A RAT MODEL WITH MILD AND SEVERE ACUTE URETER OBSTRUCTIONJournal of Urology, VOL. 160, NO. 4, (1567-1571), Online publication date: 1-Oct-1998.ANGELL S, PRUTHI R and SHORTLIFFE L (2018) THE URODYNAMIC RELATIONSHIP OF RENAL PELVIC AND BLADDER PRESSURES, AND URINARY FLOW RATE IN RATS WITH CONGENITAL VESICOURETERAL REFLUXJournal of Urology, VOL. 160, NO. 1, (150-156), Online publication date: 1-Jul-1998.Fung L and Atala A (2018) CONSTANT ELEVATION IN RENAL PELVIC PRESSURE INDUCES AN INCREASE IN URINARY N-ACETYL-beta-D-GLUCOSAMINIDASE IN A NONOBSTRUCTIVE PORCINE MODELJournal of Urology, VOL. 159, NO. 1, (212-216), Online publication date: 1-Jan-1998.COWAN B and SHORTLIFFE L (2018) OXYBUTYNIN DECREASES RENAL PELVIC PRESSURES IN NORMAL AND INFECTED RAT URINARY TRACTJournal of Urology, VOL. 160, NO. 3 Part 1, (882-886), Online publication date: 1-Sep-1998.FICHTNER J, BOINEAU F, LEWY J and SHORTLIFFE L (2018) OXYBUTYNIN LOWERS ELEVATED RENAL PELVIC PRESSURES IN A RAT CONGENITAL UNILATERAL HYDRONEPHROSISJournal of Urology, VOL. 160, NO. 3 Part 1, (887-891), Online publication date: 1-Sep-1998.Fung L, Khoury A, McLorie G, Chait P and Churchill B (2018) Pressure Decay Half-life: A Method for Characterizing Upper Urinary Tract Urine TransportJournal of Urology, VOL. 155, NO. 3, (1045-1049), Online publication date: 1-Mar-1996.Peters C (2018) Urinary Tract Obstruction in ChildrenJournal of Urology, VOL. 154, NO. 5, (1874-1884), Online publication date: 1-Nov-1995.Fung L, Khoury A, McLorie G, Chait P and Churchill B (2018) Evaluation of Pediatric Hydronephrosis Using Individualized Pressure Flow CriteriaJournal of Urology, VOL. 154, NO. 2, (671-676), Online publication date: 1-Aug-1995.Hsia T and Shortliffe L (2018) The Effect of Pregnancy on Rat Urinary Tract DynamicsJournal of Urology, VOL. 154, NO. 2, (684-689), Online publication date: 1-Aug-1995. Volume 152Issue 2 Part 2August 1994Page: 652-657 Advertisement Copyright & Permissions© 1994 by The American Urological Association Education and Research, Inc.Keywordsureteral obstructionhydronephrosisratsMetricsAuthor Information Jan Fichtner More articles by this author Frank G. Boineau More articles by this author John E. Lewy More articles by this author R.K. Sibley More articles by this author Richard C. Vari More articles by this author Linda M.D. Shortliffe More articles by this author Expand All Advertisement PDF DownloadLoading ...