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Malignant Peripheral Nerve Sheath Tumor Arising in a « De Novo » Ganglioneuroma. A Case Report

1991; SAGE Publishing; Volume: 77; Issue: 1 Linguagem: Inglês

10.1177/030089169107700121

2038-2529

Stefania Damiani, Valeria Manetto, Giovanna Carrillo, Arturo Di Blasi, Oscar Nappi, Vincenzo Eusebi,

Adrenal and Paraganglionic Tumors

A case of a « de novo » ganglioneuroma showing an internal area of malignant nerve sheath tumor is described. The tumor arose in an 18-year-old girl without a history of von Recklinghausen's disease. Immunohistochemically, the ganglioneuromatous component was positive with anti-synaptophysin, anti-S100 protein and anti-vimentin antisera, whereas the malignant part was immunoreactive only with anti-S100 protein and anti-vimentin antisera. The patient is free of disease 4 years after surgery. The clinicopathologlc features of this rare case are discussed.