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Bacterial Adherence in the Human Ileal Conduit: A Morphological and Bacteriological Study

1984; Lippincott Williams & Wilkins; Volume: 132; Issue: 1 Linguagem: Inglês

10.1016/s0022-5347(17)49516-4

1527-3792

Andrew W. Bruce, Gregor Reid, Raphael C.Y. Chan, J. W. Costerton,

Intestinal Malrotation and Obstruction Disorders

No AccessJournal of Urology1 Jul 1984Bacterial Adherence in the Human Ileal Conduit: A Morphological and Bacteriological Study Andrew W. Bruce, Gregor Reid, Raphael C.Y. Chan, and J. William Costerton Andrew W. BruceAndrew W. Bruce , Gregor ReidGregor Reid , Raphael C.Y. ChanRaphael C.Y. Chan , and J. William CostertonJ. William Costerton View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)49516-4AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail A retrospective study of 50 patients with urinary diversion was undertaken to determine the incidence of bacteriuria and upper tract infection. Eighty-four per cent of these patients developed bacteriuria caused by a variety of pathogenic organisms and 14 per cent had clinical evidence of pyelonephritis. A phased morphological and bacteriological study was then carried out in a further 17 patients with ileal conduits. Electron microscopy examination of cup biopsy specimens from superficial and deep segments of the conduit showed virtually no bacteria adhering to the columnar cells of the conduit, although Gram positive cocci were seen adhering to the keratinized cells from the muco-cutaneous junction. However, the conduit mucus was heavily colonized, initially with yeasts, then sequentially with microcolonies of Gram-positive and Gram-negative bacteria, up to 16 years after urinary diversion had been performed. Bacteriological examination of conduit and stomal mucus and urine specimens of these 17 patients confirmed the presence of large numbers of uropathogens. Of 23 conduit isolates, 9 possessed hemagglutinins, 18 of 18 attached to uroepithelial cells in vitro and 6 of 6 attached to ureteral transitional cells in vitro, indicating their adhesive and pathogenic capabilities. © 1984 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited byJung H, Lee H, Im Y, Lee Y, Hong C and Han S (2012) Prerequisite for Successful Surgical Outcome in Urothelium Lined Seromuscular ColocystoplastyJournal of Urology, VOL. 187, NO. 4, (1416-1421), Online publication date: 1-Apr-2012.Zehnder P, Dhar N, Thurairaja R, Ochsner K and Studer U (2009) Effect of Urinary Tract Infection on Reservoir Function in Patients With Ileal Bladder SubstituteJournal of Urology, VOL. 181, NO. 6, (2545-2549), Online publication date: 1-Jun-2009.MATHOERA R, KOK D, VISSER W, VERDUIN C and NIJMAN R (2018) CELLULAR MEMBRANE ASSOCIATED MUCINS IN ARTIFICIAL URINE AS MEDIATORS OF CRYSTAL ADHESION: AN IN VITRO ENTEROCYSTOPLASTY MODELJournal of Urology, VOL. 166, NO. 6, (2329-2336), Online publication date: 1-Dec-2001.Khoury A, Salomon M, Doche R, Soboh F, Ackerley C, Jayanthi R, McLorie G and Mittelman M (2018) Stone Formation After Augmentation Cystoplasty: The Role of Intestinal MucusJournal of Urology, VOL. 158, NO. 3, (1133-1137), Online publication date: 1-Sep-1997.Carlén B, Willén R and Månsson W (2018) Mucosal Ultrastructure of Continent Cecal Reservoir for Urine and its Ileal Nipple Valve 2–9 Years After ConstructionJournal of Urology, VOL. 143, NO. 2, (372-376), Online publication date: 1-Feb-1990.Månsson W, Colleen S, Löw K, Mårdh P and Lundblad A (2018) Immunoglobulins in Urine from Patients with Ileal and Colonic Conduits and ReservoirsJournal of Urology, VOL. 133, NO. 4, (713-716), Online publication date: 1-Apr-1985. Volume 132Issue 1July 1984Page: 184-188 Advertisement Copyright & Permissions© 1984 by The American Urological Association Education and Research, Inc.MetricsAuthor Information Andrew W. Bruce More articles by this author Gregor Reid More articles by this author Raphael C.Y. Chan More articles by this author J. William Costerton Current address: Dept. of Biology, University of Calgary, 2500 University Drive NW, Calgary, Alberta, Canada T2N 1N4. More articles by this author Expand All Advertisement PDF downloadLoading ...