Portal de Periódicos da CAPES

Mechanism of phenobarbital-induced hypercholeresis in the rat

1970; American Physiological Society; Volume: 219; Issue: 3 Linguagem: Inglês

10.1152/ajplegacy.1970.219.3.809

2163-5773

P. Berthelot, Serge Erlinger, Daniel Dhumeaux, Préaux Am,

Drug Solubulity and Delivery Systems

ARTICLESMechanism of phenobarbital-induced hypercholeresis in the ratP Berthelot, S Erlinger, D Dhumeaux, and AM PreauxP Berthelot, S Erlinger, D Dhumeaux, and AM PreauxPublished Online:01 Sep 1970https://doi.org/10.1152/ajplegacy.1970.219.3.809MoreSectionsPDF (1 MB)Download PDF ToolsExport citationAdd to favoritesGet permissionsTrack citations ShareShare onFacebookTwitterLinkedInWeChat Previous Back to Top Next Download PDF FiguresReferencesRelatedInformation Cited ByActivation of Constitutive Androstane Receptor (CAR) in Mice Results in Maintained Biliary Excretion of Bile Acids Despite a Marked Decrease of Bile Acids in Liver16 March 2016 | Toxicological Sciences, Vol. 151, No. 2Effects of proanthocyanidin enriched extract from Ligaria cuneifolia on plasma cholesterol and hemorheological parameters. In vivo and In vitro studiesClinical Hemorheology and Microcirculation, Vol. 60, No. 3Techniques of ExperimentationERK1/2 and p38 MAPKs Are Complementarily Involved in Estradiol 17ß-d-Glucuronide-Induced Cholestasis: Crosstalk with cPKC and PI3K14 November 2012 | PLoS ONE, Vol. 7, No. 11Effect of phenobarbitone on the biliary reabsorption of [35S]sulphobromophthalein sodium from the rat biliary tree12 April 2011 | Journal of Pharmacy and Pharmacology, Vol. 30, No. 1Medical and Nutritional Management of Cholestasis in Infants and ChildrenCholangiocyte anion exchange and biliary bicarbonate excretionWorld Journal of Gastroenterology, Vol. 12, No. 22CAR and PXR agonists stimulate hepatic bile acid and bilirubin detoxification and elimination pathways in mice1 January 2005 | Hepatology, Vol. 42, No. 2Effect of Ursodeoxycholic Acid on the Expression of the Hepatocellular Bile Acid Transporters (Ntcp and bsep) in Rats With Estrogen-Induced CholestasisJournal of Pediatric Gastroenterology and Nutrition, Vol. 35, No. 2Techniques of ExperimentationEvaluation of Hemorrheologic Parameters and Biliary Secretion in Ligaria cuneifolia (Argentine mistletoe) Extract-Treated Rats29 September 2008 | Pharmaceutical Biology, Vol. 39, No. 6Adaptive hepatic changes in mild stenosis of the common bile duct in the rat25 April 2014 | Research in Experimental Medicine, Vol. 198, No. 6Role of bile salts in colchicine-induced hepatotoxicity. Implications for hepatocellular integrity and functionToxicology, Vol. 121, No. 2Rat model of mild stenosis of the common bile ductResearch in Experimental Medicine, Vol. 196, No. 1The Use of Jejunal Transplants to Treat a Genetic Enzyme DeficiencyAnnals of Surgery, Vol. 223, No. 6Does paracellular permeability play a role in cholephilic dye-induced cholestasis?Toxicology Letters, Vol. 84, No. 1Colchicine does not inhibit secretin-induced choleresis in rats exhibiting hyperplasia of bile ductules: evidence against a pivotal role of exocytic vesicle insertionJournal of Hepatology, Vol. 22, No. 3Effects of obesity on bile formation and biliary lipid secretion in the genetically obese JCR:LA-corpulent ratHepatology, Vol. 20, No. 6Effects of phalloidin and colchicine on diethylmaleate-induced choleresis and ultrastructural appearance of rat hepatocytes10 December 2008 | Liver, Vol. 14, No. 6Effects of octreotide on biliary lipid composition and occurrence of cholesterol crystals in patients with acromegalyDigestive Diseases and Sciences, Vol. 39, No. 11Evidence for defective primary bile acid secretion in children with progressive familial intrahepatic cholestasis (Byler disease)European Journal of Pediatrics, Vol. 153, No. 6Hepatic transport of organic anions in taurolithocholate-induced cholestasis in ratsJournal of Hepatology, Vol. 20, No. 5Ursodeoxycholic acid improves ethinyl estradiol–induced cholestasis in the ratEuropean Journal of Clinical Investigation, Vol. 23, No. 12Choleretic effect of the essential oil fromHelichrysum picardii Boiss. & Reuter in ratsPhytotherapy Research, Vol. 7, No. 5Chronic administration of cyclosporin A induces a decrease in hepatic excretory function in manDigestive Diseases and Sciences, Vol. 37, No. 10The effect of felodipine on bile flow in pentobarbital anaesthetized rats and conscious rats receiving bile salt supplementationEuropean Journal of Drug Metabolism and Pharmacokinetics, Vol. 17, No. 4Bile salt-associated electrolyte secretionExperimental and Toxicologic Pathology, Vol. 44, No. 6Primary intrahepatic cholesterol stonesDigestive Diseases and Sciences, Vol. 37, No. 9Maintenance of liver function in long term culture of hepatocytes following In Vitro or In Vivo Ha-ras EJ transfectionCell Biology and Toxicology, Vol. 7, No. 4Choleretic action of andrographolide obtained fromAndrographis paniculata in ratsPhytotherapy Research, Vol. 5, No. 4Inhibition by colchicine of biliary secretion of diethylmaleate in the rat: Evidence for microtubule-dependent vesicular transportHepatology, Vol. 14, No. 1Transcellular transport of organic anions in hepatocytes: Still a long way to goHepatology, Vol. 14, No. 1Effect of chronic administration of cyclosporin A on hepatic uptake and biliary secretion of bromosulfophthalein in ratDigestive Diseases and Sciences, Vol. 36, No. 2Studies on the mechanism of bile salt-independent bile flow impairment in streptozotocin-induced hepatotoxicityToxicology, Vol. 68, No. 3Cholic acid and chenodeoxycholic acid transport in the hepatic acinus in rats: Effect of necrosis of zone 3 induced by bromobenzene10 December 2008 | Liver, Vol. 10, No. 6Pharmacologic Approaches to the Prevention and Treatment of Neonatal HyperbilirubinemiaClinics in Perinatology, Vol. 17, No. 2Inhibition and induction of bile acid synthesis by ketoconazole effects on bile formation in the ratLipids, Vol. 24, No. 9Choleresis and increased biliary efflux of glutathione induced by phenolic antioxidants in ratsToxicology, Vol. 52, No. 3The effect of methimazole on bile flow and bile acid secretion in the ratBiochemical Pharmacology, Vol. 37, No. 4Role of the hepatocyte microtubular system in the excretion of bile salts and biliary lipid: implications for intracellular vesicular transport.Journal of Lipid Research, Vol. 29, No. 2Effect of various bile salts on calcium concentration and calcium carbonate saturation of rat bileJournal of Hepatology, Vol. 7, No. 1Phenobarbital specifically increases the hepatocellular uptake of sulfobromophthalein-glutathioneBiochemical and Biophysical Research Communications, Vol. 149, No. 3Effect of colchicine and phalloidin on the distribution of three plasma membrane antigens in rat hepatocytes: Comparison with bile duct ligationHepatology, Vol. 7, No. 6Toxic effect of streptozotocin on the biliary secretion of nicotinamide-treated ratsToxicology Letters, Vol. 36, No. 3Bile flow decrease and altered bile composition in streptozotocin-treated ratsBiochemical Pharmacology, Vol. 35, No. 15Effect of systemic pH, PCO2 and bicarbonate concentration on biliary bicarbonate secretion in the ratHepatology, Vol. 5, No. 4Acute effects of pentobarbital-anaesthesia on bile secretionBiochemical Pharmacology, Vol. 34, No. 10Effect of aging on the hepatobiliary transport of dimeric immunoglobulin A in the male fischer ratGastroenterology, Vol. 88, No. 2The Role of Bile Acids in the Effect of Ethinylestradiol on the Biliary Excretion of Exogenous Organic AnionsPigment Gallstones of the Common Bile Duct in InfancyHepatology, Vol. 4, No. 4Reversible impairment of hepatobiliary function induced by streptozotocin in the ratExperientia, Vol. 40, No. 3Techniques of ExperimentationPrimary cultures of rat hepatocytes as a model system of canalicular development, biliary secretion, and intrahepatic cholestasisGastroenterology, Vol. 84, No. 6Excretion MechanismsSerum bile acid levels in intrahepatic cholestasis of pregnancy during treatment with phenobarbital or cholestyramineEuropean Journal of Obstetrics & Gynecology and Reproductive Biology, Vol. 14, No. 3Effect of ursodeoxycholate on the bile flow in the ratLife Sciences, Vol. 31, No. 18Stereoselective formation of bromobenzene glutathione conjugatesChemico-Biological Interactions, Vol. 41, No. 2Interaction of Insulin, Glucagon, and DBcAMP on Bile Acid-Independent Bile Production in the Rat19 February 2010 | Scandinavian Journal of Gastroenterology, Vol. 17, No. 5Mechanism of Bile FormationGastroenterology, Vol. 83, No. 1Phenobarbital-induced alterations of bile acid metabolism in cases of intrahepatic cholestasisKlinische Wochenschrift, Vol. 60, No. 11Secretin enhances [14C]erythritol clearance in unanesthetized dogsDigestive Diseases and Sciences, Vol. 27, No. 1Pharmacokinetics and drug distribution during postnatal developmentPharmacology & Therapeutics, Vol. 18, No. 2Studies on the Enterohepatic Circulation of Bile Acids in Infancy and Childhood.Pediatrics International, Vol. 23, No. 3Functional implications of liver cell heterogeneityGastroenterology, Vol. 80, No. 2Influence of colchicine and phalloidin on bile secretion and hepatic ultrastructure in the ratGastroenterology, Vol. 79, No. 4Bile acids and their sulphated and glucuronidated derivatives in bile, plasma, and urine of children with intrahepatic cholestasis: effects of phenobarbital treatmentEuropean Journal of Clinical Investigation, Vol. 10, No. 4Hypercholeresis induced by ursodeoxycholic acid and 7-ketolithocholic acid in the rat: Possible role of bicarbonate transportGastroenterology, Vol. 79, No. 1Glucuronidation of bilirubin and the occurrence of pigment gallstones in patients with chronic haemolytic diseasesEuropean Journal of Clinical Investigation, Vol. 10, No. 3Bile formation and biliary lipid composition under the influence of clofibrate and phenobarbital pretreatment in the ratNaunyn-Schmiedeberg's Archives of Pharmacology, Vol. 308, No. 2Cation-anion gap and choleretic properties of rat bile.C Klos, G Paumgartner, and J Reichen1 April 1979 | American Journal of Physiology-Endocrinology and Metabolism, Vol. 236, No. 4Bile flow in response to pharmacologic agentsBiochemical Pharmacology, Vol. 28, No. 7General IntroductionPhalloidin-induced cholestasis in the rat: Relation to changes in microfilamentsGastroenterology, Vol. 75, No. 3Influence of phenylbutazone on bile flow in the ratExperientia, Vol. 34, No. 5Excretory Liver Function TestsClinics in Gastroenterology, Vol. 7, No. 2Studies on bile secretion with the aid of the isolated perfused rat liver. II. The effect of two further pentacyclic triterpenes, asiatic acid and 22β-angeloyloxyoleanolic acidChemico-Biological Interactions, Vol. 21, No. 1A possible mechanism of choleretic action of 3-(2,4,5-triethoxybenzoyl)-propoionic acid (AA-149) in dogsEuropean Journal of Pharmacology, Vol. 48, No. 1The influence of various bile salts and some cholephilic dyes on Na+, K+- and Mg2+-activated ATPase of rat liver in relation to cholestatic effectsToxicology and Applied Pharmacology, Vol. 43, No. 3Phenobarbital-induced increase of NADH-cytochrome b5 reductase activity in rat liver microsoniesBiochemical Pharmacology, Vol. 27, No. 3Hepatic bilirubin UDP-glucuronyltransferase in patients with sickle cell anemiaGastroenterology, Vol. 74, No. 2Clinical consequences of microsomal enzyme-induction by antiepileptic drugsPharmacology & Therapeutics. Part C: Clinical Pharmacology and Therapeutics, Vol. 2, No. 3-4Metabolism of 3-(2′,4′,5′-Triethoxybenzoyl)propionic Acid, a New Biliary Smooth Muscle Relaxant with Choleretic Activity: II. Metabolism after Repeated Dosing in Rats, in Relation to Choleretic Activity22 September 2008 | Xenobiotica, Vol. 8, No. 6Biliary Excretion1 January 2011The biliary excretion of bucolome in the rat: A possible cause for choleresisBiochemical Pharmacology, Vol. 26, No. 24Disturbances of Bile Acid Metabolism in CholestasisClinics in Gastroenterology, Vol. 6, No. 1Studies on Increased Bile Formation Produced by Polyoxybenzenes in RatsJapanese Journal of Pharmacology, Vol. 27, No. 1Neonatal Hepatitis: A Diagnostic ApproachAdvances in Pediatrics, Vol. 24, No. 1Hepatic Bile FormationNew England Journal of Medicine, Vol. 295, No. 27Effects of acetylcholine and atropine on the bile flow and biliary excretion of digoxin in the isolated perfused rat liverNaunyn-Schmiedeberg's Archives of Pharmacology, Vol. 295, No. 2The metabolism of 2-allyl-2-isopropylacetamide in vivo and in the isolated perfused rat liverBiochemical Pharmacology, Vol. 25, No. 22Different Effects of Microsomal Enzyme Inducers on the Biliary Excretion of Digoxin113 March 2009 | Acta Pharmacologica et Toxicologica, Vol. 39, No. 4Jaundice in pregnancy—1976The American Journal of Medicine, Vol. 61, No. 3Hepatic microsomal mixed function oxidase system response to selective biliary obstructionBiochimica et Biophysica Acta (BBA) - General Subjects, Vol. 444, No. 2Alteration of drug metabolism in Gilbert's syndrome.Gut, Vol. 17, No. 8Phenobarbital as a hypocholesterolemic agent in the rat and rabbitMetabolism, Vol. 25, No. 7Site of bile acid absorption in the ratLipids, Vol. 11, No. 6Bile Acids in Hepato-Biliary DiseasesHepatic Transport of Bile AcidsConjugation of Bilirubin — Pathophysiological AspectsBiliary Excretion of Metals22 September 2008 | Drug Metabolism Reviews, Vol. 5, No. 2Biochemical Studies on Bile SecretionBile Duct Function in Biliary SecretionProstaglandin-induced choleresis in the ratExperientia, Vol. 31, No. 10Biliary Excretion of Xenobiotics14 February 2011 | CRC Critical Reviews in Toxicology, Vol. 4, No. 1Phenobarbital-enhanced biliary excretion of administered unconjugated and conjugated sulfobromophthalein (BSP) in the ratBiochemical Pharmacology, Vol. 24, No. 13-14Reduced bile flow in rats during sulfobromophthalein infusionToxicology and Applied Pharmacology, Vol. 32, No. 2Effects of phenobarbital upon bile acid synthesis in two strains of ratsLipids, Vol. 10, No. 3Bile salts and bile formation in rats, rabbits and guinea pigsComparative Biochemistry and Physiology Part A: Physiology, Vol. 50, No. 3Effect of Phenobarbital in a Case of Extrahepatic CholestasisGastroenterology, Vol. 68, No. 3Canalicular Bile Production in ManEuropean Journal of Clinical Investigation, Vol. 5, No. 1Principles of Biliary SecretionThe Enterohepatic CirculationEffect of nafenopin (SU-13,437) on liver functionNaunyn-Schmiedeberg's Archives of Pharmacology, Vol. 290, No. 2-3THE HEPATIC TRANSPORT OF SODIUM TAUROCHOLATE IN THE RAT: EFFECT OF PHENOBARBITONEClinical and Experimental Pharmacology and Physiology, Vol. 1, No. 6Changes in in vivo metabolism of bile acids in rat after treatment with phenobarbitalLipids, Vol. 9, No. 11Drugs and the liver—IBiochemical Pharmacology, Vol. 23, No. 20Failure qf phenobarbital to increase bilirubin production in the ratBiochemical Pharmacology, Vol. 23, No. 20The effect of phenobarbital and sodium dehydrocholate on the biliary excretion of methylmercury in the ratToxicology and Applied Pharmacology, Vol. 30, No. 1Effect of Phenobarbital on Liver Functions in Patients with Dubin-Johnson SyndromeGastroenterology, Vol. 67, No. 2Bile Salt Metabolism and Bile Formation in the Rat with a Portacaval Shunt2 March 2011 | European Journal of Clinical Investigation, Vol. 4, No. 4Influence of Portacaval Shunt on Bile Formation in the Rat*2 March 2011 | European Journal of Clinical Investigation, Vol. 4, No. 3Bile salts and liver disease in childhoodPostgraduate Medical Journal, Vol. 50, No. 584Effect of chloroquine and phenobarbital on morphine glucuronidation and biliary excretion in the ratBiochemical Pharmacology, Vol. 23, No. 8Mechanisms and Control of Secretion of Bile Water and ElectrolytesGastroenterology, Vol. 66, No. 2Influence of Portacaval Shunt on Bile Formation in the RatEuropean Journal of Clinical Investigation, Vol. 4, No. 1Bile Salt Metabolism and Bile Formation in the Rat with a Portacaval ShuntEuropean Journal of Clinical Investigation, Vol. 4, No. 1Metabolism of 6-Chloro-5-cyclohexylindan-1-carboxylic Acid (TAI-284), a New Non-steroidal Anti-inflammatory Agent, in Relation to Ulcerogenic Activity16 April 2010 | Xenobiotica, Vol. 4, No. 10Bile Salts: A Determinant of the Bile-Peritoneal Electrical Potential Difference in the RatGastroenterology, Vol. 65, No. 6Effect of Phenobarbital on the Ethynyl Estradiol-Induced Cholestasis in the RatGastroenterology, Vol. 65, No. 4Determination of the biliary dead space usign14C-taurocholate as a markerExperientia, Vol. 29, No. 9Changes in bilipubin cleapance under phenobarbital treatment in patients with various cholaemic syndpomesPharmacological Research Communications, Vol. 5, No. 2Mechanisms and prediction of drug-induced liver disease.Gut, Vol. 14, No. 4Bile SecretionClinics in Gastroenterology, Vol. 2, No. 1Effect of phenobarbital on the volume of the biliary tree in the rat1 December 1972 | Experientia, Vol. 28, No. 12Biliary Excretion of Mercury Enhanced by SpironolactoneGastroenterology, Vol. 63, No. 6Effects of phenobarbital and rose bengal on the ATPases of plasma membranes of rat and rabbit liverGut, Vol. 13, No. 11The Effects of Phenobarbital on Bile Salts and Bilirubin in Patients with Intrahepatic and Extrahepatic CholestasisNew England Journal of Medicine, Vol. 286, No. 16Effect of Chronic Ethanol Feeding on Bile Formation and Secretion of Lipids in the RatGastroenterology, Vol. 62, No. 2Alterations in Liver Plasma Membranes and their Possible Role in CholestasisGastroenterology, Vol. 62, No. 2Effect of phenobarbitone on hepatic microsomal enzymes of the male ratBiochemical Pharmacology, Vol. 21, No. 1PROBENECID TEST IN PARKINSON'S DISEASEThe Lancet, Vol. 298, No. 7736INTRAVASCULAR COAGULATION IN PRE-ECLAMPSIAThe Lancet, Vol. 298, No. 7736HEPATITIS-ASSOCIATED ANTIGEN IN HUMAN BILEThe Lancet, Vol. 298, No. 7736The cholestatic syndrome—1971The American Journal of Medicine, Vol. 51, No. 5Effect of phenobarbital on bile flow and bile salt excretion in the ratNaunyn-Schmiedebergs Archiv f�r Pharmakologie, Vol. 270, No. 1 More from this issue > Volume 219Issue 3September 1970Pages 809-813 Copyright & PermissionsCopyright © 1970 by American Physiological Societyhttps://doi.org/10.1152/ajplegacy.1970.219.3.809PubMed5450891History Published online 1 September 1970 Published in print 1 September 1970 Metrics