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Protein and substrate metabolism during starvation and parenteral refeeding

1988; Portland Press; Volume: 74; Issue: 2 Linguagem: Inglês

10.1042/cs0740123

1470-8736

Kevin J. Tracey, Adrian Legaspi, James D. Albert, Malayappa Jeevanandam, Dwight E. Matthews, Murray F. Brennan, Stephen F. Lowry,

Muscle metabolism and nutrition

1. Healthy male volunteers underwent 10 days of hospitalized protein-calorie starvation and a subsequent 10 day repletion phase with complete intravenous nutritional support (IVF). Non-protein calories were provided as either all d-glucose or as 50% d-glucose/50% lipid. 2. In comparison with starvation, whole-body protein breakdown, as assessed by [15N]glycine, [13C]leucine and urinary excretion of 3-methylhistidine (3-MH), was diminished during IVF. The administration of parenteral nutrition did not specifically suppress peripheral tissue protein breakdown, as measured by extremity 3-MH efflux. 3. Despite the differential insulin response to d-glucose/amino acid (50 ± 6 m-units/ml) as compared with the d-glucose/lipid/amino acid regimen (25 ± 4 m-units/ml), there was no difference in nitrogen retention between the regimens. Indirect calorimetric determinations revealed that oxidation of substrate during IVF was related to the proportion of d-glucose and lipid infusion.