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Gastroprotective effect of (-)-myrtenol against ethanol-induced acute gastric lesions: possible mechanisms

2016; Oxford University Press; Volume: 68; Issue: 8 Linguagem: Inglês

10.1111/jphp.12583

2042-7158

Ana Flávia Seraine Custódio Viana, Francilene Vieira da Silva Freitas, Hélio de Barros Fernandes, Irisdalva Sousa Oliveira, Milena Aguiar Braga, Paulo Iury Gomes Nunes, Daniel de Araújo Viana, Damião Pergentino de Sousa, V. S. N. Rao, Rita de Cássia Meneses Oliveira, Flávia Almeida Santos,

Biochemical Analysis and Sensing Techniques

Abstract Objectives (-)-Myrtenol is a natural fragrance monoterpenoid structurally related to α-pinene found in diverse plant essential oils. This study was aimed to assess the anti-ulcerogenic potential of (-)-myrtenol against ethanol-induced gastric lesions and to elucidate the underlying mechanism(s). Methods Gastroprotective activity of (-)-myrtenol was evaluated using the mouse model of ethanol-induced gastric damage. To elucidate the gastroprotective mechanism(s), the roles of GABA, prostaglandins, nitric oxide and KATP channels were assessed. Besides, the oxidative stress-related parameters and the mucus content in gastric tissues were analysed. Key findings (-)-Myrtenol at oral doses of 25, 50 and 100 mg/kg significantly decreased the severity of ethanol-induced gastric lesions affording gastroprotection that was accompanied by a decrease in the activity of myeloperoxidase and malondialdehyde, an increase in GPx, SOD, and catalase activity in gastric tissues, and with well-maintained normal levels of nitrite/nitrate, gastric mucus and NP-SHs. Pretreatment with GABA-A receptor antagonist flumazenil, the COX inhibitor indomethacin, and NO synthesis inhibitor L-NAME but not with KATP channel blocker glibenclamide significantly blocked the (-)-myrtenol gastroprotection. Conclusion These results provide first-time evidence for the gastroprotective effect of (-)-myrtenol that could be related to GABAA-receptor activation and antioxidant activity.