Treatment of Genitourinary Rhabdomyosarcoma in Children
1984; Lippincott Williams & Wilkins; Volume: 132; Issue: 2 Linguagem: Inglês
10.1016/s0022-5347(17)49607-8
ISSN1527-3792
AutoresFereshteh Ghavimi, H.W. Herr, Berta Jereb, Philip R. Exelby,
Tópico(s)Vascular Tumors and Angiosarcomas
ResumoWe report on 27 children with rhabdomyosarcoma of the bladder, prostate, uterus, cervix and vagina treated with combined therapy of surgery, radiotherapy and multiple drug chemotherapy. Of the 27 patients 18 are alive for 13 to 147 months (median 86 months) and 9 have retained a functional bladder. Extirpative surgery followed by adjuvant chemotherapy and occasionally radiation therapy was most effective for local tumor control and 7 of 10 patients survived, including 5 with an intact functional bladder. Primary use of chemotherapy in 13 patients with extensive disease resulted in complete tumor control in only 3 but 7 survived, including 4 with an intact bladder. Radiation therapy used concomitantly with chemotherapy failed to control the local tumor but with subsequent extirpative surgery all 4 patients survived.
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