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Vascular Effects of a Sulfated Polysaccharide from the Red Marine Alga Solieria Filiformis

2010; SAGE Publishing; Volume: 5; Issue: 8 Linguagem: Inglês

10.1177/1934578x1000500825

1934-578X

Ana Maria Sampaio Assreuy, Grazielle C. Pontes, Natália Velloso Fontenelle Camelo Rodrigues, Daniel ML Gomes, Paulo A. Xavier, Glácio Souza Araújo, Alexandre Holanda Sampaio, Benildo Sousa Cavada, Maria G. Pereira, Wladimir Ronald Lobo Farias,

Marine Sponges and Natural Products

Anticoagulant and antithrombotic properties of sulfated-polysaccharides (SP) from marine algae are extensively exploited. However, reports on the vascular effects of SP from red algae are rare in the literature. The polysaccharide from Solieria filiformis (Sf-SP) was isolated by ion exchange chromatography, analyzed by agarose gel electrophoresis and tested in male Wistar rats. The inflammation studies were performed using the paw-edema model and the relaxant activity in isolated aorta pre-contracted with phenylephrine. The anticoagulant effect was evaluated by the test of partial thromboplastin activation time. The SP (1 mg/kg) was not anti-inflammatory, but induced acute edema with maximal activity at 30 min (0.35 +/- 0.04 mL) compared to controls (0.05 +/- 0.03 mL). Cumulative addition of Sf-SP in phenylephrine-contracted tissues produced relaxation with maximal inhibition of 69% (IC50 29.3 +/- 9.0 microg/mL) at 300 microg/mL in comparison to controls (0.51 +/- 0.09 g). Sf-SP also extended human plasma coagulation time by 2.1 times. These substances could be used as important tools for the study of vascular alterations.