Age-related Changes in Bone Mineral Density, Mean Width and Area of the Lumbar Vertebrae in Male African Green Monkeys (<I>Cercopithecus aethiops</I>)
1994; Volume: 43; Issue: 2 Linguagem: Inglês
10.1538/expanim1978.43.2_235
ISSN1884-4170
AutoresAkio Hiyaoka, Takashi Yoshida, Fumiaki Cho, Yasuhiro Yoshikawa,
Tópico(s)Stress Responses and Cortisol
ResumoWe were able to measure bone mineral density (BMD), mean bone width and the area of the lumbar vertebrae in male African green monkeys with a dual-energy X-ray absorptiometry (DPX-α, Lunar, USA) . For analysis of spinal bone mass, mean width and area of the bone, we scanned lumbar vertebrae L3-L5 using a pediatric analysis program. We used restraining bed made of formed polystyrol to support the animal in a supine position. The precision of the measuring technique was calculated by averaging the coefficients of variance of the 5 scans obtained in 5 animals aged from 5 to 7 years. The precision values for BMD, bone width and area were 1.9%, 0.9% and 2.6%, respectively. Furthermore, age-related changes in bone measurements were demonstrated using laboratory-bred males (n=45) and, additionally, wild-originated males (n=7, estimated ages over 15 years old) . The values of B M D, bone width and area at 6 months old were about 0.3g/cm2, 1.2cm and 4.5 cm2 respectively. These values increased with aging to about 0.7 g/cm2, 1.5 cm and 11cm2 at 5 years old, respectively, and were judged to reach plateau. However, animals over 10 years old and wild-originated animals which had been kept over 10 years in our breeding colony showed rather smaller BMD and area values than the animals aged 5 to 10 years. The animals aged between 5 and 10 years seemed to have retained a peak bone mass in this primate species.
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