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Identification of a High Risk Subgroup of Grade 1 Transitional Cell Carcinoma Using Image Analysis Based Deoxyribonucleic Acid Ploidy Analysis of Tumor Tissue

1991; Lippincott Williams & Wilkins; Volume: 146; Issue: 6 Linguagem: Inglês

10.1016/s0022-5347(17)38157-0

1527-3792

George P. Hemstreet, Scott A. Rollins, Philip L. Jones, Jian Yu Rao, Robert E. Hurst, Rebecca B. Bonner, Tommy Hewett, Bobby G. Smith,

Renal cell carcinoma treatment

No AccessJournal of Urology1 Dec 1991Identification of a High Risk Subgroup of Grade 1 Transitional Cell Carcinoma Using Image Analysis Based Deoxyribonucleic Acid Ploidy Analysis of Tumor Tissue George P. Hemstreet, Scott Rollins, Philip Jones, Jian Yu Rao, Robert E. Hurst, Rebecca Bass Bonner, Tommy Hewett, and Bobby G. Smith George P. HemstreetGeorge P. Hemstreet More articles by this author , Scott RollinsScott Rollins More articles by this author , Philip JonesPhilip Jones More articles by this author , Jian Yu RaoJian Yu Rao More articles by this author , Robert E. HurstRobert E. Hurst More articles by this author , Rebecca Bass BonnerRebecca Bass Bonner More articles by this author , Tommy HewettTommy Hewett More articles by this author , and Bobby G. SmithBobby G. Smith More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)38157-0AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail The use of deoxyribonucleic acid (DNA) cytometry to identify a subset of patients with grade 1, stage Ta or T1 transitional cell carcinoma at high risk for death or recurrence was investigated in a retrospective study using paraffin blocks from 88 low grade transitional cell carcinomas of the bladder with an absorptiometric video-based image analysis system. Tumors were evaluated for ploidy (70 diploid, 16 aneuploid and 2 tetraploid) and the presence of cells with greater than 5C DNA. Survival analysis of 62 patients with adequate followup (15 to 20 years) showed that 43 of 62 (69%) suffered recurrences and 13 (21%) died of bladder cancer. The single most important predictors of death and recurrence were stem line aneuploidy and the presence of cells with greater than 5C DNA, respectively. © 1991 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited byvan VELTHOVEN R, PETEIN M, OOSTERLINCK W, DE WILDE T, MATTELAER J, HARDEMAN M, KISS R and DECAESTECKER C (2018) IDENTIFICATION BY QUANTITATIVE CHROMATIN PATTERN ANALYSIS OF PATIENTS AT RISK FOR RECURRENCE OF SUPERFICIAL TRANSITIONAL BLADDER CARCINOMAJournal of Urology, VOL. 164, NO. 6, (2134-2137), Online publication date: 1-Dec-2000. (2018) EDITORIAL COMMENTJournal of Urology, VOL. 161, NO. 3, (808-809), Online publication date: 1-Mar-1999.Slaton J, Dinney C, Veltri R, Miller M, Liebert M, O'Dowd G and Grossman H (2018) Deoxyribonucleic Acid Ploidy Enhances the Cytological Prediction of Recurrent Transitional Cell Carcinoma of the BladderJournal of Urology, VOL. 158, NO. 3, (806-811), Online publication date: 1-Sep-1997.Mora L, Nicosia S, Pow-Sang J, Ku N, Diaz J, Lockhart J and Einstein A (2018) Ancillary Techniques in the Followup of Transitional Cell Carcinoma: A Comparison of Cytology, Histology and Deoxyribonucleic Acid Image Analysis Cytometry in 91 PatientsJournal of Urology, VOL. 156, NO. 1, (49-55), Online publication date: 1-Jul-1996.Tachibana M, Miyakawa A, Nakamura K, Baba S, Murai M and Tazaki H (2018) Role of Proliferative Activity Estimated by Bromodeoxyuridine Labeling Index in Determining Predictive Factors of Recurrence in Superficial Intermediately Malignant Bladder TumorsJournal of Urology, VOL. 156, NO. 1, (63-69), Online publication date: 1-Jul-1996.Prout G, Barton B, Griffin P and Friedell G (2018) Treated History of Noninvasive Grade 1 Transitional Cell CarcinomaJournal of Urology, VOL. 148, NO. 5 Part 1, (1413-1419), Online publication date: 1-Nov-1992. Volume 146Issue 6December 1991Page: 1525-1529 Advertisement Copyright & Permissions© 1991 by The American Urological Association Education and Research, Inc.Keywordscarcinoma, transitional cellDNA, neoplasmflow cytometrybladder neoplasmsMetricsAuthor Information George P. Hemstreet More articles by this author Scott Rollins More articles by this author Philip Jones More articles by this author Jian Yu Rao More articles by this author Robert E. Hurst More articles by this author Rebecca Bass Bonner More articles by this author Tommy Hewett More articles by this author Bobby G. Smith More articles by this author Expand All Advertisement PDF downloadLoading ...