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Progression Delay of Prostate Tumor Skeletal Metastasis Effects by Bisphosphonates

1992; Lippincott Williams & Wilkins; Volume: 148; Issue: 4 Linguagem: Inglês

10.1016/s0022-5347(17)36890-8

1527-3792

Yucheng Sun, Albert A. Geldof, Don Newling, B. Ramanath Rao,

Bone health and treatments

No AccessJournal of Urology1 Oct 1992Progression Delay of Prostate Tumor Skeletal Metastasis Effects by Bisphosphonates Sun Yu-Cheng, Albert A. Geldof, Don W.W. Newling, and B. Ramanath Rao Sun Yu-ChengSun Yu-Cheng , Albert A. GeldofAlbert A. Geldof , Don W.W. NewlingDon W.W. Newling , and B. Ramanath RaoB. Ramanath Rao View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)36890-8AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Prostate tumor cell metastasis to the axial skeleton was induced in male Copenhagen rats using the intravenous injection of syngeneic metastatic R3327-MATLyLu tumor cells and concomitant caval vein clamping. The proliferation of tumor cells in the lumbar region was monitored by the progression, within 19 days post tumor cell injection, of hindleg paralysis which appeared in these animals. Histology confirmed the presence of tumor cells within the lumbar spine in 100% of cases displaying hindleg paralysis. Treatment with either of the bisphosphonate drugs, C12MDP or APD, suppressed and delayed the development of hind leg paralysis. Bisphosphonate treatment may be expected to delay the onset of axial skeletal metastasis effects in prostate cancer patients. © 1992 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited byBERRUTI A, DOGLIOTTI L, TUCCI M, TARABUZZI R, FONTANA D and ANGELI A (2018) METABOLIC BONE DISEASE INDUCED BY PROSTATE CANCER: RATIONALE FOR THE USE OF BISPHOSPHONATESJournal of Urology, VOL. 166, NO. 6, (2023-2031), Online publication date: 1-Dec-2001.Horan A (2018) Re: Osteoporosis as a complication of Orchiectomy in 2 Elderly Men with Prostatic CancerJournal of Urology, VOL. 155, NO. 4, (1395-1395), Online publication date: 1-Apr-1996. Volume 148Issue 4October 1992Page: 1270-1273 Advertisement Copyright & Permissions© 1992 by The American Urological Association Education and Research, Inc.Keywordsprostatic neoplasmsbisphosphonatesneoplasm metastasisboneMetricsAuthor Information Sun Yu-Cheng More articles by this author Albert A. Geldof More articles by this author Don W.W. Newling More articles by this author B. Ramanath Rao More articles by this author Expand All Advertisement PDF downloadLoading ...