Artigo Acesso aberto Revisado por pares

Soluble interleukin-2 receptors in the sera of patients with hairy cell leukemia: relationship with the effect of recombinant alpha-interferon therapy on clinical parameters and natural killer in vitro activity

1987; Elsevier BV; Volume: 70; Issue: 5 Linguagem: Inglês

10.1182/blood.v70.5.1530.1530

ISSN

1528-0020

Autores

Marco Chilosi, Gianpietro Semenzato, Cetto Gl, Alberto Ambrosetti, L Fiore-Donati, G. Perona, Giorgio Berton, Maurizio Lestani, Aldo Scarpa, Carlo Agostini,

Tópico(s)

Lymphoma Diagnosis and Treatment

Resumo

Abstract In this study we provide evidence that the sera of patients with hairy cell leukemia (HCL) contain a factor that can prevent the binding of a monoclonal antibody specific for interleukin-2 receptor (IL-2R) to its target. This factor corresponds to the soluble form of IL-2R (sIL-2R), as assessed by a specific enzyme-linked immunosorbent assay test, and appears to be released by neoplastic hairy cells. The serum sIL-2R levels were very high at diagnosis and significantly reduced during recombinant alpha-interferon (rIFN alpha 2) therapy. Values of sIL-2R appeared to be inversely related to the natural killer in vitro function displayed by peripheral blood mononuclear cells from the same patients. The presence of sIL-2R in the serum of patients with HCL might be involved in the impairment of cell-mediated immunity observed in these patients and could represent a valuable marker for monitoring different phases of the disease and for modulating IFN therapy.

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