Soluble interleukin-2 receptors in the sera of patients with hairy cell leukemia: relationship with the effect of recombinant alpha-interferon therapy on clinical parameters and natural killer in vitro activity
1987; Elsevier BV; Volume: 70; Issue: 5 Linguagem: Inglês
10.1182/blood.v70.5.1530.1530
ISSN1528-0020
AutoresMarco Chilosi, Gianpietro Semenzato, Cetto Gl, Alberto Ambrosetti, L Fiore-Donati, G. Perona, Giorgio Berton, Maurizio Lestani, Aldo Scarpa, Carlo Agostini,
Tópico(s)Lymphoma Diagnosis and Treatment
ResumoAbstract In this study we provide evidence that the sera of patients with hairy cell leukemia (HCL) contain a factor that can prevent the binding of a monoclonal antibody specific for interleukin-2 receptor (IL-2R) to its target. This factor corresponds to the soluble form of IL-2R (sIL-2R), as assessed by a specific enzyme-linked immunosorbent assay test, and appears to be released by neoplastic hairy cells. The serum sIL-2R levels were very high at diagnosis and significantly reduced during recombinant alpha-interferon (rIFN alpha 2) therapy. Values of sIL-2R appeared to be inversely related to the natural killer in vitro function displayed by peripheral blood mononuclear cells from the same patients. The presence of sIL-2R in the serum of patients with HCL might be involved in the impairment of cell-mediated immunity observed in these patients and could represent a valuable marker for monitoring different phases of the disease and for modulating IFN therapy.
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