Portal de Periódicos da CAPES

The Effect of an Alpha-2 Agonist on Bladder Function and Cord Histology after Spinal Cord Injury

1990; Lippincott Williams & Wilkins; Volume: 144; Issue: 6 Linguagem: Inglês

10.1016/s0022-5347(17)39791-4

1527-3792

Robert E. Weiss, John J. Tomasula, Jose R. Sotolongo,

Spinal Cord Injury Research

No AccessJournal of Urology1 Dec 1990The Effect of an Alpha-2 Agonist on Bladder Function and Cord Histology after Spinal Cord Injury Robert Weiss, John J. Tomasula, and Jose R. Sotolongo Robert WeissRobert Weiss More articles by this author , John J. TomasulaJohn J. Tomasula More articles by this author , and Jose R. SotolongoJose R. Sotolongo More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)39791-4AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Spinal injury in cats is accompanied by urinary bladder and hind limb dysfunction. Ten cats subjected to spinal contusion at the ninth thoracic segment were treated with guanabenz (an alpha-2 agonist) intraperitoneally (0.65mg./kg.) three hours after injury, and twice daily for eight weeks. An additional six spinal cats were untreated and served as controls. Urodynamic studies were performed on a weekly basis on all animals. Guanabenz modified the vesico-somatic reflex: detrusor-sphincter dyssynergia was either ablated or abolished. In contrast, the controls demonstrated detrusor-sphincter dyssynergia, high residual urine, and spasticity below the lesion. Histological evaluations of the spinal cords revealed that the six paraplegic animals (untreated) suffered marked cavitation of the cord and complete destruction of the grey matter. The five incomplete paraplegic animals (treated) showed minimal cavitation with some preservation of the grey matter. The five ambulators (treated) demonstrated some distortion of grey matter with preservation of white matter. Treatment with guanabenz post traumatic cord injury results in decreased cord cavitation. Detrusor-sphincter dyssynergia is diminished and hind limb function is improved in treated animals. © 1990 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited ByHarada T and Constantinou C (2018) The Effect of Alpha2 Agonists and Antagonists on the Lower Urinary Tract of the RatJournal of Urology, VOL. 149, NO. 1, (159-164), Online publication date: 1-Jan-1993. Volume 144Issue 6December 1990Page: 1527-1530 Advertisement Copyright & Permissions© 1990 by The American Urological Association Education and Research, Inc.MetricsAuthor Information Robert Weiss More articles by this author John J. Tomasula More articles by this author Jose R. Sotolongo More articles by this author Expand All Advertisement Loading ...