Portal de Periódicos da CAPES

Effects of Fasting on Plasma and Platelet-Free Fatty Acids and Platelet Function in Healthy Males

1976; Thieme Medical Publishers (Germany); Volume: 36; Issue: 02 Linguagem: Inglês

10.1055/s-0038-1648048

2567-689X

Knut Gjesdal, Arne Nordøy, Harald Wang, Harald Berntsen, Ole D. Μjøs,

Dietary Effects on Health

Summary 10 healthy male volunteers fasted for 72 hours. Their plasma concentration of free fatty acid increased more than two-fold, to 1.8 mmol/1. The number of reversible venous “in vivo” platelet aggregates increased significantly (p <0.01); this figure correlated with the concentration of long-chain saturated free fatty acid in plasma (p <0.02). The correlation with the amount of long-chain saturated free fatty acid plus oleic acid (18:1) was even better (p <0.01). Plasma PF-4 concentration increased, suggesting increased platelet release reaction. In spite of the plasma increase, total platelet FFA concentration was reduced and there was a change in the distribution of platelet free fatty acid which correlated with the degree of aggregation.