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Dependence on glutamine uptake and glutamine addiction characterize myeloma cells: a new attractive target

2016; Elsevier BV; Volume: 128; Issue: 5 Linguagem: Inglês

10.1182/blood-2016-01-690743

1528-0020

Marina Bolzoni, Martina Chiu, Fabrizio Accardi, Rosanna Vescovini, Irma Airoldi, Paola Storti, Katia Todoerti, Luca Agnelli, Gabriele Missale, Roberta Andreoli, Massimiliano G. Bianchi, Manfredi Allegri, Amelia Barilli, Francesco Nicolini, A. Cavalli, Federica Costa, Valentina Marchica, Denise Toscani, Cristina Mancini, Eugenia Martella, Valeria Dall’Asta, Gaetano Donofrío, Franco Aversa, Ovidio Bussolati, Nicola Giuliani,

Cancer, Hypoxia, and Metabolism

Key Points Myeloma cells produce ammonium in the presence of glutamine, showing high glutaminase and low glutamine synthetase expression. Myeloma cells show high expression of glutamine transporters and inhibition of ASCT2 transporter hinders myeloma growth.