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Evidence for a lentiviral etiology in an epizootic of immune deficiency and lymphoma in stump‐tailed macaques ( Macaca arctoides )

1992; Wiley; Volume: 21; Issue: 1 Linguagem: Inglês

10.1111/j.1600-0684.1992.tb00618.x

1600-0684

Linda J. Lowenstine, Nicholas W. Lerche, JoAnn L. Yee, Ann Uyeda, Myra B. Jennings, Robert J. Munn, Harold M. McClure, Daniel C. Anderson, Patricia N. Fultz, Murray B. Gardner,

Cytomegalovirus and herpesvirus research

A retrospective study determined that an epizootic of immune suppression and lymphoma in stump‐tailed macaques ( Macaca arctoides ) that began in 1976 was associated with a horizontally spread lentivirus infection. This conclusion was based on serology, epidemiology, pathology, and virus isolation. The lesions found in the stump‐tailed macaques were more compatible with lesions seen in SIV‐infected rhesus than those seen in rhesus macaques infected with type D retroviruses. A lentivirus, isolated from a rhesus inoculated with lymph node homogenate from a stump‐tailed macaque, was designed SIVstm and was pathogenic for rhesus macaques. The isolate was antigenically related to other SIVs as well as to HIV‐1 and HIV‐2. Two surviving stump‐tailed macaques sent to another colony carried SIVstm latently for at least 7 years and disseminated it throughout that colony.