The role of calcium in the regulation of apoptosis
1996; Oxford University Press; Volume: 59; Issue: 6 Linguagem: Inglês
10.1002/jlb.59.6.775
ISSN1938-3673
AutoresDavid J. McConkey, Sten Orrenius,
Tópico(s)Protein Kinase Regulation and GTPase Signaling
ResumoAbstract The recognition that apoptosis is regulated by an evolutionarily conserved set of polypeptides from the nematode Caenorhabditis elegant to humans suggests that a conserved set of biochemical mechanism(s) may also be involved in the response. Work from a number of independent laboratories suggests that alterations in cytosolic Ca2+ homeostasis represent one such candidate mechanism, and molecular targets for Ca2+ are now being identified. This review will summarize what is known about the role of Ca2+ in the regulation of apoptosis and discuss how Ca2+ might interact with some of the other biochemical signals implicated in cell death.
Referência(s)