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Effect of cervical vagosympathectomy on myocardial catecholamine concentration

1965; American Physiological Society; Volume: 209; Issue: 5 Linguagem: Inglês

10.1152/ajplegacy.1965.209.5.951

2163-5773

Max Jellinek, Michael P. Kaye, George C. Kaiser, Theodore Cooper,

Cardiac pacing and defibrillation studies

Dogs which survived a bilateral cervical vagosympathectomy showed a striking reduction in catecholamine concentration of right atrial tissue. Significant decreases in catecholamine concentration were noted also in the tissues of both ventricles and the interventricular septum. Unilateral cervical vagosympathectomy, either right or left, was not followed by a statistically significant decrease in the concentration of cardiac catecholamines. The cause of the depletion after bilateral cervical vagosympathectomy is not clear. It may be due to destruction of intracardiac adrenergic nerves or a relatively increased utilization of catecholamines, which exceeds the capacity of the cardiac tissues to synthesize, take up, or bind these substances. The concentrations of cardiac histamine and nitrogen were unaffected by these operative procedures.