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Physical and Chemical Analyses of the Mineral Substance during the Development o f Two Experimental Cutaneous Calcifications in Rats: Topical Calciphylaxis and Topical Calcergy

1983; De Gruyter; Volume: 38; Issue: 1-2 Linguagem: Inglês

10.1515/znc-1983-1-223

1865-7125

H. J. Tochon-Danguy, Georges Boivin, Michel Geoffroy, Claude Walzer, C. A. Baud,

Erythrocyte Function and Pathophysiology

In subcutaneous calcinoses induced in rats by topical calciphylaxis and topical calcergy, the ultrastructural aspects related to the evolution of calcified deposits were previously described. In the present study by means of X-ray diffraction, infrared spectrometry and electron spin resonance, different biophysical analyses are performed on the mineral substance deposited during development of calciphylaxis and calcergy. A rapid evolution of the calcium phosphate deposits into hydroxyapatite was noticed along the first 20 days of the calcinoses; from then, there is no important modification even at the later stages, and the characteristics of the mineral substance are mostly similar to that of bone tissue. The concentration of trace elements such as Mg 2+ and Fe 2+ , is found higher in cutaneous calcinoses than in bone tissue.