Portal de Periódicos da CAPES

Effects of Methoxamine and a-Adrenoceptor Antagonists, Prazosin and Yohimbine, on the Sleep-Wake Cycle of the Rat

1984; Oxford University Press; Volume: 7; Issue: 4 Linguagem: Inglês

10.1093/sleep/7.4.365

1550-9109

Teresa Pellejero, Jaime M. Monti, J. B. Baglietto, Héctor Jantos, Sheila Pazos, Victor Cichevski, Marjorie Hawkins,

Receptor Mechanisms and Signaling

A study was carried out on the effects of methoxamine, prazosin, and yohimbine on the sleep-wake cycle in rats prepared for chronic sleep recordings. Methoxamine (4-8 mg/kg), an alpha 1-adrenoceptor agonist, induced a dose-related increase in wakefulness (W) and a decrease in slow-wave sleep (SWS) and REM sleep (REMS). Prazosin (0.125-1 mg/kg), which selectively blocks alpha 1-adrenoceptors, modified only slightly the amount of time spent in W and SWS, and consistently decreased REMS values. Prazosin (0.5 mg/kg) reversed the effects of methoxamine, decreasing W and increasing sleep. Yohimbine (3 mg/kg), which blocks alpha 2-adrenoceptors, augmented W and diminished sleep. Methoxamine (4 mg/kg) in animals pretreated with yohimbine (3 mg/kg) induced a further decrease of SWS and REMS and an increase of W. Thus, pharmacological activation of alpha 1- or blocking of alpha 2-adrenoceptors appears to decrease sleep and increase W. Further, blocking of alpha 1-adrenoceptors decreases REMS. Rapid eye movement sleep depression by the alpha 1-agonist or the alpha 1-antagonist is tentatively ascribed to a critical change in noradrenergic transmission in the brain.