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Immunohistochemical Detection of Carcinoembryonic Antigen in Benign Hyperplasia and Adenocarcinoma of the Prostate with Monoclonal Antibody

1984; Lippincott Williams & Wilkins; Volume: 131; Issue: 3 Linguagem: Inglês

10.1016/s0022-5347(17)50466-8

1527-3792

Mohammad Ghazizadeh, Susumu Kagawa, Keisuke Izumi, Koji Maebayashi, Hiroshi Takigawa, Takashi Saiki, Akira Kawano, Kazuo Kurokawa,

Cell Adhesion Molecules Research

No AccessJournal of Urology1 Mar 1984Immunohistochemical Detection of Carcinoembryonic Antigen in Benign Hyperplasia and Adenocarcinoma of the Prostate with Monoclonal Antibody Mohammad Ghazizadeh, Susumu Kagawa, Keisuke Izumi, Koji Maebayashi, Hiroshi Takigawa, Takashi Saiki, Akira Kawano, and Kazuo Kurokawa Mohammad GhazizadehMohammad Ghazizadeh More articles by this author , Susumu KagawaSusumu Kagawa More articles by this author , Keisuke IzumiKeisuke Izumi More articles by this author , Koji MaebayashiKoji Maebayashi More articles by this author , Hiroshi TakigawaHiroshi Takigawa More articles by this author , Takashi SaikiTakashi Saiki More articles by this author , Akira KawanoAkira Kawano More articles by this author , and Kazuo KurokawaKazuo Kurokawa More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)50466-8AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Immunoperoxidase localization of carcinoembryonic antigen was done on tissue sections of benign hyperplasia and adenocarcinoma of the prostate using murine monoclonal antibody against carcinoembryonic antigen. The study was done to determine whether carcinoembryonic antigen would be a tissue marker of prostatic malignancy. Of 30 benign lesions 25 (83 per cent) were negative and 5 had focally weak staining, while of 36 adenocarcinomas 31 (86 per cent) had diffusely positive staining and 5 were negative. Diffusely moderate or strong staining was noted in 5 of 10 grade I (50 per cent), 11 of 12 (92 per cent) grade II and 13 of 14 (93 per cent) grade III tumors, as well as 14 of 15 (93 per cent) tumors from patients with bone metastasis. These findings suggested that extensive immunostaining for carcinoembryonic antigen in prostatic glandular lesions might be a potentially important prognostic marker of malignancy. Further studies are warranted to extend and confirm these results. © 1984 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited ByGhazizadeh M, Kagawa S and Kurokawa K (2018) Immunohistochemical Studies of Human Renal Cell Carcinomas for ABO(H) Blood Group Antigens, T Antigen-Like Substance and Carcinoembryonic AntigenJournal of Urology, VOL. 133, NO. 5, (762-766), Online publication date: 1-May-1985.Ghazizadeh M, Kagawa S, Izumi K and Kurokawa K (2018) Immunohistochemical Localization of T Antigen-Like Substance in Benign Hyperplasia and Adenocarcinoma of the ProstateJournal of Urology, VOL. 132, NO. 6, (1127-1130), Online publication date: 1-Dec-1984. Volume 131Issue 3March 1984Page: 501-503 Advertisement Copyright & Permissions© 1984 by The American Urological Association Education and Research, Inc.MetricsAuthor Information Mohammad Ghazizadeh More articles by this author Susumu Kagawa More articles by this author Keisuke Izumi More articles by this author Koji Maebayashi More articles by this author Hiroshi Takigawa More articles by this author Takashi Saiki More articles by this author Akira Kawano More articles by this author Kazuo Kurokawa More articles by this author Expand All Advertisement PDF DownloadLoading ...