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Cancer Treatment as an Accelerated Aging Process: Assessment, Biomarkers, and Interventions

2016; American Society of Clinical Oncology; Issue: 36 Linguagem: Inglês

10.1200/edbk_156160

1930-7020

Arti Hurria, Lee W. Jones, Hyman B. Muss,

Radiation Therapy and Dosimetry

An accumulating body of evidence supports the hypothesis that cancer and/or cancer treatment is associated with accelerated aging. The majority of these data come from the pediatric literature; however, a smaller yet growing body of literature points toward similar findings in the geriatric population. This is a key survivorship issue the growing number of older adults with cancer face, along with the short- and long-term impact of cancer therapy on the aging process. This article will review clinical and biologic markers of aging in older adults with cancer, use cardiovascular disease as a model of accelerated aging, and discuss potential interventions to decrease the risk.