Glutamate and other CSF amino acids in Alzheimer's disease
1992; American Psychiatric Association; Volume: 149; Issue: 2 Linguagem: Inglês
10.1176/ajp.149.2.251
ISSN1535-7228
AutoresNunzio Pomara, Rajkumar Singh, Dennis Deptula, J Chou, Marlene B. Schwartz, Peter A. LeWitt,
Tópico(s)Cholinesterase and Neurodegenerative Diseases
ResumoBack to table of contents Previous article Next article No AccessGlutamate and other CSF amino acids in Alzheimer's diseasePublished Online:1 Apr 2006https://doi.org/10.1176/ajp.149.2.251AboutSectionsView articleAbstractPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack Citations ShareShare onFacebookTwitterLinked InEmail View articleAbstractThe authors compared CSF amino acid levels of 10 patients with mild to moderate dementia and probable Alzheimer's disease who had never received antidepressant or neuroleptic medication with those of 10 normal subjects of similar age. The Alzheimer's patients had significantly higher levels of CSF glutamate. This finding was not related to age, sex, or severity of dementia. Elevated CSF glutamate may reflect greater glutamatergic activity early in the course of Alzheimer's disease. The authors speculate that the excitotoxic effects of glutamate may contribute to progressive neuronal loss in Alzheimer's disease. 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59, No. 2Trends in Neurosciences, Vol. 16, No. 9 Volume 149Issue 2 February 1992Pages 251-254 Metrics PDF download History Published online 1 April 2006 Published in print 1 February 1992
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