Efficacy of lithium-tranylcypromine treatment in refractory depression
1985; American Psychiatric Association; Volume: 142; Issue: 5 Linguagem: Inglês
10.1176/ajp.142.5.619
ISSN1535-7228
AutoresL H Price, Dennis S. Charney, George R. Heninger,
Tópico(s)Child and Adolescent Psychosocial and Emotional Development
ResumoBack to table of contents Previous article Next article No AccessEfficacy of lithium-tranylcypromine treatment in refractory depressionPublished Online:1 Apr 2006https://doi.org/10.1176/ajp.142.5.619AboutSectionsView articleAbstractPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack Citations ShareShare onFacebookTwitterLinked InEmail View articleAbstractTwelve inpatients with major depression refractory to at least two controlled antidepressant trials had tranylcypromine added to ongoing lithium treatment. Eleven patients showed reliable improvement in nurses' depression ratings compared with a prior trial of lithium added to an antidepressant that was not a monoamine oxidase inhibitor (MAOI). Eight patients were blindly judged much or very much improved, and all 12 patients improved sufficiently to be discharged. Preclinical studies of conjointly administered lithium and MAOIs suggest that central serotonergic pathways may mediate this robust clinical effect. 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FiguresReferencesCited byDetailsCited by60 Years of Combining TranylcypromineJournal of Clinical Psychopharmacology, Vol. 42, No. 1European Neuropsychopharmacology, Vol. 27, No. 8Monoamine oxidase inhibitorsSynthesis and Biochemical Evaluation of Fluorinated Monoamine Oxidase InhibitorsPolypharmazie in der Behandlung depressiver StörungenAdvances in Psychiatric Treatment, Vol. 11, No. 1CNS Spectrums, Vol. 9, No. S14Monoamine Oxidase Inhibitors RevisitedPsychiatric Annals, Vol. 31, No. 6Journal of Affective Disorders, Vol. 59Advances in Psychiatric Treatment, Vol. 4, No. 6A Review of the Use of Augmentation Therapy for the Treatment of Resistant Depression: Implications for the Clinician26 June 2016 | Australian & New Zealand Journal of Psychiatry, Vol. 31, No. 3MANAGEMENT OF TREATMENT-RESISTANT UNIPOLAR AND CHRONICALLY DEPRESSED PATIENTSPsychiatric Clinics of North America, Vol. 19, No. 2TREATMENT ALGORITHMS IN TREATMENT-RESISTANT DEPRESSIONPsychiatric Clinics of North America, Vol. 19, No. 2Treatment of Acute Bipolar Depression: A Review of the Literature1 November 1995 | The Canadian Journal of Psychiatry, Vol. 40, No. 9Treatment-Resistant Depression: A Critique of Current Approaches26 June 2016 | Australian & New Zealand Journal of Psychiatry, Vol. 28, No. 1Depression, Vol. 2, No. 3Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 18, No. 2Commentary on 'The management of treatment-resistant affective disorder: clinical perspectives'1 July 2016 | Journal of Psychopharmacology, Vol. 6, No. 2Treatment-Resistant Depression: A Survey of Practice Habits of Canadian Psychiatrists1 June 1991 | The Canadian Journal of Psychiatry, Vol. 36, No. 5International Review of Psychiatry, Vol. 3, No. 1Prophylactic Medication for Unipolar Depressive Illness: The Place of Lithium Carbonate in Combination with Antidepressant Medication1 March 1990 | The Canadian Journal of Psychiatry, Vol. 35, No. 2A View of Psychopharmacology, Neuroscience, and the Major PsychosesJournal of Affective Disorders, Vol. 18, No. 3Irish Journal of Psychological Medicine, Vol. 7, No. 2The Journal of Psychology, Vol. 124, No. 1British Journal of Psychiatry, Vol. 154, No. 5Combined drug therapy for an elderly depressed patient1 April 2006 | American Journal of Psychiatry, Vol. 145, No. 8Tolerance of a high dose of haloperidol by an elderly patient1 April 2006 | American Journal of Psychiatry, Vol. 145, No. 8The combination of lithium carbonate and an MAOI in refractory depressions1 April 2006 | American Journal of Psychiatry, Vol. 145, No. 2Medical Clinics of North America, Vol. 72, No. 4British Journal of Psychiatry, Vol. 153, No. 3The Pharmacological Treatment of Tricyclic-Resistant Depression: Review and Management Guidelines26 June 2016 | Australian & New Zealand Journal of Psychiatry, Vol. 21, No. 4Lithium in Depression: A Review of the Antidepressant and Prophylactic Effects of Lithium26 June 2016 | Australian & New Zealand Journal of Psychiatry, Vol. 21, No. 3Treatment-Resistant DepressionPsychiatric Annals, Vol. 17, No. 4Cellular and Molecular Neurobiology, Vol. 7, No. 3British Journal of Psychiatry, Vol. 151, No. 2Variability of response to lithium augmentation in refractory depression1 April 2006 | American Journal of Psychiatry, Vol. 143, No. 11Lithium Addition in Treatment-Resistant Depression1 November 1986 | The Canadian Journal of Psychiatry, Vol. 31, No. 8Lithium-antidepressant combinations in the treatment of depressed, physically ill geriatric patients1 April 2006 | American Journal of Psychiatry, Vol. 143, No. 3Stress Medicine, Vol. 2, No. 2, Vol. 10Life Sciences, Vol. 37, No. 9 Volume 142Issue 5 May 1985Pages 619-623 Metrics PDF download History Published online 1 April 2006 Published in print 1 May 1985
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