Portal de Periódicos da CAPES

Teratoma Following Cisplatin-Based Combination Chemotherapy for Nonseminomatous Germ Cell Tumors: A Clinicopathological Correlation

1986; Lippincott Williams & Wilkins; Volume: 135; Issue: 6 Linguagem: Inglês

10.1016/s0022-5347(17)46031-9

1527-3792

Patrick J. Loehrer, Siu Hui, Steven A. Clark, Mark Seal, Lawrence H. Einhorn, Stephen D. Williams, Thomas M. Ulbright, Isadore Mandelbaum, Randall G. Rowland, John P. Donohue,

Vascular Tumors and Angiosarcomas

No AccessJournal of Urology1 Jun 1986Teratoma Following Cisplatin-Based Combination Chemotherapy for Nonseminomatous Germ Cell Tumors: A Clinicopathological Correlation Patrick J. Loehrer, Siu Hui, Steven Clark, Mark Seal, Lawrence H. Einhorn, Stephen D. Williams, Thomas Ulbright, Isadore Mandelbaum, Randall Rowland, and John P. Donohue Patrick J. LoehrerPatrick J. Loehrer , Siu HuiSiu Hui , Steven ClarkSteven Clark , Mark SealMark Seal , Lawrence H. EinhornLawrence H. Einhorn , Stephen D. WilliamsStephen D. Williams , Thomas UlbrightThomas Ulbright , Isadore MandelbaumIsadore Mandelbaum , Randall RowlandRandall Rowland , and John P. DonohueJohn P. Donohue View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)46031-9AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail From April 1975 through May 1981, 51 patients had teratoma resected from residual disease following cisplatin-based combination chemotherapy. All patients had normal serum markers before resection of abdominal (25), lung (12), mediastinal (5), thoracoabdominal (8) or other (1) disease. Teratoma was classified as mature in 29 cases, immature in 15 or immature with nongerm cell elements in 7. Of the 51 patients 31 (61 per cent) remain free of recurrent disease, while 20 either had recurrent carcinoma (10) or teratoma (10) requiring further therapy. Nine patients died, including 1 in whom angiosarcoma developed, which was thought to be secondary to previous radiation therapy. In 4 patients the initial relapse of carcinoma developed beyond 2 years after resection. Univariate factors predicting for relapse include tumor burden, immature teratoma with nongerm cell elements and site (mediastinum), while only immature teratoma with nongerm cell elements and site predicted for survival. Patients with immature teratoma had a comparable relapse-free and over-all survival as those with mature teratoma. Using a multivariate analysis, primary tumor site at the mediastinum was the most significant adverse factor predictive for relapse and survival. This study appears to support the various pre-clinical models that demonstrate multipotential capabilities of teratoma. Complete surgical excision of teratoma remains the most effective treatment with continued close followup recommended for high risk patients (immature teratoma with nongerm cell elements, large tumor burden and primary mediastinal tumors) with resected teratoma. © 1986 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited ByLeão R, van Agthoven T, Figueiredo A, Jewett M, Fadaak K, Sweet J, Ahmad A, Anson-Cartwright L, Chung P, Hansen A, Warde P, Castelo-Branco P, O'Malley M, Bedard P, Looijenga L and Hamilton R (2018) Serum miRNA Predicts Viable Disease after Chemotherapy in Patients with Testicular Nonseminoma Germ Cell TumorJournal of Urology, VOL. 200, NO. 1, (126-135), Online publication date: 1-Jul-2018.Beck S, Foster R, Bihrle R, Einhorn L and Donohue J (2018) Long-Term Outcome for Patients With High Volume Retroperitoneal Teratoma Undergoing Post-Chemotherapy SurgeryJournal of Urology, VOL. 181, NO. 6, (2526-2532), Online publication date: 1-Jun-2009.SHEINFELD J, MOTZER R, RABBANI F, McKIERNAN J, BAJORIN D and BOSL G (2018) Incidence and Clinical Outcome of Patients with Teratoma in the Retroperitoneum Following Primary Retroperitoneal Lymph Node Dissection for Clinical Stages I and IIA Nonseminomatous Germ Cell TumorsJournal of Urology, VOL. 170, NO. 4 Part 1, (1159-1162), Online publication date: 1-Oct-2003.COMITER C, KIBEL A, RICHIE J, NUCCI M and RENSHAW A (2018) PROGNOSTIC FEATURES OF TERATOMAS WITH MALIGNANT TRANSFORMATION: A CLINICOPATHOLOGICAL STUDY OF 21 CASESJournal of Urology, VOL. 159, NO. 3, (859-863), Online publication date: 1-Mar-1998.Heidenreich A, Moul J, McLeod D, Mostofi F and Engelmann U (2018) The Role of Retroperitoneal Lymphadenectomy in Mature Teratoma of the TestisJournal of Urology, VOL. 157, NO. 1, (160-163), Online publication date: 1-Jan-1997.Hejase M, Donohue J, Foster R, Bihrle R, Coogan C, Rowland R and Wahle G (2018) Post-Chemotherapy Resection of Nonseminomatous Germ Cell Testicular Tumors Metastatic to the MediastinumJournal of Urology, VOL. 156, NO. 4, (1345-1348), Online publication date: 1-Oct-1996.Little J, Foster R, Ulbright T and Donohue J (2018) Unusual Neoplasms Detected in Testis Cancer Patients Undergoing Post-Chemotherapy Retroperitoneal LymphadenectomyJournal of Urology, VOL. 152, NO. 4, (1144-1151), Online publication date: 1-Oct-1994.Parker M, Russo P, Reuter V, Bosl G and Keefe D (2018) Intracardiac Teratoma 15 Years After Treatment of a Nonseminomatous Germ Cell TumorJournal of Urology, VOL. 150, NO. 2 Part 1, (478-480), Online publication date: 1-Aug-1993.Sella A, El Naggar A, Ro J, Dexeus F, Amato R, Lee J, Finn L and Logothetis C (2018) Evidence of Malignant Features in Histologically Mature TeratomaJournal of Urology, VOL. 146, NO. 4, (1025-1028), Online publication date: 1-Oct-1991.Lotherington Qvist H, Fosså S, Ous S, Høie J, Stenwig A and Giercksky K (2018) Post-Chemotherapy Tumor Residuals in Patients with Advanced Nonseminomatous Testicular Cancer. Is it Necessary to Resect All Residual Masses?Journal of Urology, VOL. 145, NO. 2, (300-302), Online publication date: 1-Feb-1991.Richie J (2018) Editorial CommentsJournal of Urology, VOL. 145, NO. 2, (302-303), Online publication date: 1-Feb-1991.FossÅ S, Aass N, Ous S, Høie J, Stenwig A, Lien H, Paus E and Kaalhus O (2018) Histology of Tumor Residuals Following Chemotherapy in Patients with Advanced Nonseminomatous Testicular CancerJournal of Urology, VOL. 142, NO. 5, (1239-1242), Online publication date: 1-Nov-1989.Fosså S, Ous S, Lien H and Stenwig A (2018) Post-Chemotherapy Lymph Node Histology in Radiologically Normal Patients with Metastatic Nonseminomatous Testicular CancerJournal of Urology, VOL. 141, NO. 3 Part 1, (557-559), Online publication date: 1-Mar-1989. Volume 135Issue 6June 1986Page: 1183-1189 Advertisement Copyright & Permissions© 1986 by The American Urological Association Education and Research, Inc.MetricsAuthor Information Patrick J. Loehrer More articles by this author Siu Hui More articles by this author Steven Clark More articles by this author Mark Seal More articles by this author Lawrence H. Einhorn More articles by this author Stephen D. Williams More articles by this author Thomas Ulbright More articles by this author Isadore Mandelbaum More articles by this author Randall Rowland More articles by this author John P. Donohue More articles by this author Expand All Advertisement PDF DownloadLoading ...