Portal de Periódicos da CAPES

Peripheral Neuropathy Associated With Immunoglobulin Disorders An Immunological and Ultrastructural Study

1981; Springer Nature; Linguagem: Inglês

10.1007/978-3-642-81553-9_76

0065-1435

E. Nardelli, Sergio Pizzighella, Giuseppe Tridente, N. Rizzuto,

Inflammatory Myopathies and Dermatomyositis

Light-, electron microscopic and immunopathological findings in a nerve biopsy of a patient with peripheral neuropathy associated with monoclonal gammopathy are reported. Loss of fibers, Wallerian-like degeneration and segmental demyelination were the most important features observed in light microscopy. In E.M. widening of the peripheral lamellae of myelin sheaths and occasional aspects of hypermyelination were seen. Immunoperoxidase study showed binding of IgM (k light chain) on the myelin sheath. The possible pathogenetic implications of these findings are discussed.