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Tacalcitol ointment for psoriasis.

1994; National Institutes of Health; Volume: 186; Linguagem: Inglês

Mikio Nishimura, Yoshio Makino, H. Matugi,

Dermatology and Skin Diseases

Transdermal absorption of tacalcitol from the ointment containing 2 micrograms/g was studied using hairless rat and human skin. In the animal experiments, a non-negligible amount of tacalcitol was absorbed transdermally, whereas in the case of human skin, this compound was hardly absorbed at all. A placebo-controlled double-blind right/left comparison confirmed that this ointment is effective and safe for the treatment of psoriasis.