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Diagnostic Methods in the Detection of Prostate Cancer: A Study of a Randomly Selected Population of 2,400 Men

1992; Lippincott Williams & Wilkins; Volume: 148; Issue: 6 Linguagem: Inglês

10.1016/s0022-5347(17)37041-6

1527-3792

Ove Gustafsson, Ulf Norming, Lars-Erik Almgård, A Fredriksson, Göran Gustavsson, Bengt Harvig, Claes R. Nyman,

Molecular Biology Techniques and Applications

No AccessJournal of Urology1 Dec 1992Diagnostic Methods in the Detection of Prostate Cancer: A Study of a Randomly Selected Population of 2,400 Men Ove Gustafsson, Ulf Norming, Lars-Erik Almgård, Åke Fredriksson, Göran Gustavsson, Bengt Harvig, and Claes R. Nyman Ove GustafssonOve Gustafsson , Ulf NormingUlf Norming , Lars-Erik AlmgårdLars-Erik Almgård , Åke FredrikssonÅke Fredriksson , Göran GustavssonGöran Gustavsson , Bengt HarvigBengt Harvig , and Claes R. NymanClaes R. Nyman View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)37041-6AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail We investigated the value of digital rectal examination, transrectal ultrasonography and prostatic specific antigen (PSA) analysis as aids in general clinical practice and in the early detection of prostate cancer. Of a randomly selected population of 2,400 men 55 to 70 years old who were offered examination with digital rectal examination, transrectal ultrasound and PSA analysis, 1,782 (74%) accepted and prostate cancer was detected in 65 (3.6%). When the transrectal ultrasound results were also considered the detection rate of digital rectal examination (2.3%) was increased by 50% and the number of stage T2A or less tumors was doubled. At reexamination due to markedly high PSA values (7μg./l. or more) only a few additional cancers (5%) were detected. However, it is noteworthy that 80% of the detected cancers were found among the subgroup with abnormal PSA values (4μg./l. or more) and comprising 17% of the study population, which suggests the possibility of selecting a risk group at mass screening. Moreover, the positive predictive value increased from 4% (when only digital rectal examination was positive) to 71% for the combination of positive digital rectal examination, positive transrectal ultrasound and an increased PSA concentration (that is 7μg./l. or greater). © 1992 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited ByKjellman A, Akre O, Norming U, Törnblom M and Gustafsson O (2009) 15-Year Followup of a Population Based Prostate Cancer Screening StudyJournal of Urology, VOL. 181, NO. 4, (1615-1621), Online publication date: 1-Apr-2009.Ito K, Yamamoto T, Miyakubo M, Takechi H, Ohi M, Shibata Y and Suzuki K (2018) Lead Time of Prostate Cancer Detected in Population Based Screening for Prostate Cancer in JapanJournal of Urology, VOL. 178, NO. 4, (1258-1264), Online publication date: 1-Oct-2007.HUGOSSON J, AUS G, LILJA H, LODDING P, PIHL C and PILEBLAD E (2018) Prostate Specific Antigen Based Biennial Screening is Sufficient to Detect Almost All Prostate Cancers While Still CurableJournal of Urology, VOL. 169, NO. 5, (1720-1723), Online publication date: 1-May-2003.Higashihara E, Nutahara K, Kojima M, Okegawa T, Miura I, Miyata A, Kato M, Sugisaki H and Tomaru T (2018) Significance of Serum Free Prostate Specific Antigen in the Screening of Prostate CancerJournal of Urology, VOL. 156, NO. 6, (1964-1968), Online publication date: 1-Dec-1996.Feightner J (2018) The Early Detection and Treatment of Prostate Cancer: The Perspective of the Canadian Task Force on The Periodic Health ExaminationJournal of Urology, VOL. 152, NO. 5 Part 2, (1682-1684), Online publication date: 1-Nov-1994. Volume 148Issue 6December 1992Page: 1827-1831 Advertisement Copyright & Permissions© 1992 by The American Urological Association Education and Research, Inc.Keywordsdiagnosispalpationprostatic neoplasmsultrasonic diagnosisantigens, neoplasmMetricsAuthor Information Ove Gustafsson More articles by this author Ulf Norming More articles by this author Lars-Erik Almgård More articles by this author Åke Fredriksson More articles by this author Göran Gustavsson More articles by this author Bengt Harvig More articles by this author Claes R. Nyman More articles by this author Expand All Advertisement Loading ...