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Predictors of bone mass in healthy older men in the community

2000; Wiley; Volume: 173; Issue: 4 Linguagem: Inglês

10.5694/j.1326-5377.2000.tb125597.x

1326-5377

Peter Smerdely, Marilyn Seller, Angela Smith, Peter Day, Terrence Diamond,

Vitamin D Research Studies

Objectives To determine the predictors of bone mass (in lumbar spine and femoral neck) in healthy older men living in the community. Design Cross-sectional study. Bone mineral density (BMD) was measured and known predictors of bone mass and bone turnover were assessed. Subjects and setting 113 independent, healthy men (70 years and over), not taking glucocorticoid therapy and without medical conditions known to affect bone mass and bone turnover, were recruited from recreational and sports clubs in southern Sydney in April/May 1997. Main outcome measures BMD (measured by dual-energy x-ray absorptiometry); known predictors of bone mass (height; weight; body mass index; calcium level; serum 25-hydroxyvitamin D and free testosterone levels); and markers of bone turnover (serum bone Gia protein and procollagen-1 concentrations, and urinary deoxypyridinoline excretion rates). Results The mean age of the men was 76.6 years (range, 70-92 years). Mean (SE) BMD of the lumbar spine was 1.143 (0.019) g/cm2 and that of the femoral neck was 0.897 (0.013) g/cm2. BMD values indicating osteoporosis were found in the lumbar spine in 13 men (11.5%) and in the femoral neck in 35 men (31%). The best predictor of lumbar spine BMD was weight (R=0.37; P=0.001), and weight- and age-predicted femoral-neck BMD (R= 0.49; P< 0.001). The study group was analysed in two groups with BMD higher or lower than median bone mass corrected for age. Men with lower femoral-neck BMD for age had significantly lower weight, lower lean mass and higher bone Gia protein concentrations. In addition, men with lower lumbar spine BMD for age also had significantly lower fat mass. Conclusions These data indicate that measures of body composition, such as weight and lean mass, are the main predictors of bone mass in healthy, community-dwelling older men.