Single-field total lymphoid irradiation in the treatment of refractory rejection after heart transplantation.
1998; National Institutes of Health; Volume: 17; Issue: 11 Linguagem: Inglês
Autores
Trachiotis Gd, Johnston Ts, Vega Jd, Crocker Ir, Neile Chesnut, Lutz Jf, Smith Al, Kanter Kr,
Tópico(s)Organ Transplantation Techniques and Outcomes
ResumoNine heart transplant recipients were treated with single-field total lymphoid irradiation (TLI) for early ( 1 year) rejection that was refractory to multiple regimens of immunosuppressive therapy. For patients with early rejection (n = 6), the rejection frequency (rejections/patient/month) decreased from pre-TLI of 1.63 to post-TLI of .02 (p < .001), and for patients with late rejection (n = 3), the rejection frequency decreased from pre-TLI of .23 to post-TLI of .05 (p < .02). The reduced rejection frequencies have been maintained for a mean follow-up of 28.6 (8 to 78) months, and adverse events during or late after TLI were uncommon. Single-field TLI is a safe and effective technique in the management of refractory rejection early or late after heart transplantation.
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