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The Underlying Molecular Mechanism of Apolipoprotein E Polymorphism: Relationships to Lipid Disorders, Cardiovascular Disease, and Alzheimer’s Disease

1996; Elsevier BV; Volume: 16; Issue: 1 Linguagem: Inglês

10.1016/s0272-2712(18)30290-7

1557-9832

John H. Contois, Denise E. Anamani, Gregory J. Tsongalis,

Cholesterol and Lipid Metabolism

Apolipoprotein E (apo E) polymorphism has important clinical correlates, including disorders of lipoprotein metabolism and atherosclerosis. This article provides a detailed methodology for apo E genotyping and discusses the link between apo E genotype and type III hyperlipoproteinemia, coronary heart disease (CHD), stroke, and Alzheimer's disease (AD). Although apo E genotype appears to provide significant information concerning the genetic component of CHD and AD risk, more research is needed before genotyping can be recommended as a routine screening tool. The data so far, however, implicate apo E as a major component of the genetic basis of cardiovascular disease and AD.