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Vaginal Inflammation: Association between Leukocyte Concentration and Levels of Immune Mediators
2016; Wiley; Volume: 75; Issue: 2 Linguagem: Inglês
10.1111/aji.12475
ISSN1600-0897
AutoresJoziani Beghini, Paulo César Giraldo, José Eleutério, Rose Luce Gomes do Amaral, Nádia Cristina Polpeta, Ana Katherine Gonçalves,
Tópico(s)Reproductive Physiology in Livestock
ResumoAmerican Journal of Reproductive ImmunologyVolume 75, Issue 2 p. 126-133 Original Article Vaginal Inflammation: Association between Leukocyte Concentration and Levels of Immune Mediators Joziani Beghini, Corresponding Author Joziani Beghini Department of Gynecology and Obstetrics, University of Campinas, Campinas, Brazil Correspondence Joziani Beghini, Divisão de Ginecologia. CAISM – UNICAMP, Rua Alexander Fleming 101, Campinas, SP 13083-970, Brazil. E-mail: jozibeghini@yahoo.com.brSearch for more papers by this authorPaulo C. Giraldo, Paulo C. Giraldo Department of Gynecology and Obstetrics, University of Campinas, Campinas, BrazilSearch for more papers by this authorJosé Eleutério Jr, José Eleutério Jr Department of Motherhood and Child, Federal University of Ceará, Fortaleza, BrazilSearch for more papers by this authorRose Luce do Amaral, Rose Luce do Amaral Department of Gynecology and Obstetrics, University of Campinas, Campinas, BrazilSearch for more papers by this authorNádia C. Polpeta, Nádia C. Polpeta Department of Gynecology and Obstetrics, University of Campinas, Campinas, BrazilSearch for more papers by this authorAna Katherine Gonçalves, Ana Katherine Gonçalves Department of Gynecology and Obstetrics, Federal University of Rio Grande do Norte, Natal, BrazilSearch for more papers by this author Joziani Beghini, Corresponding Author Joziani Beghini Department of Gynecology and Obstetrics, University of Campinas, Campinas, Brazil Correspondence Joziani Beghini, Divisão de Ginecologia. CAISM – UNICAMP, Rua Alexander Fleming 101, Campinas, SP 13083-970, Brazil. E-mail: jozibeghini@yahoo.com.brSearch for more papers by this authorPaulo C. Giraldo, Paulo C. Giraldo Department of Gynecology and Obstetrics, University of Campinas, Campinas, BrazilSearch for more papers by this authorJosé Eleutério Jr, José Eleutério Jr Department of Motherhood and Child, Federal University of Ceará, Fortaleza, BrazilSearch for more papers by this authorRose Luce do Amaral, Rose Luce do Amaral Department of Gynecology and Obstetrics, University of Campinas, Campinas, BrazilSearch for more papers by this authorNádia C. Polpeta, Nádia C. Polpeta Department of Gynecology and Obstetrics, University of Campinas, Campinas, BrazilSearch for more papers by this authorAna Katherine Gonçalves, Ana Katherine Gonçalves Department of Gynecology and Obstetrics, Federal University of Rio Grande do Norte, Natal, BrazilSearch for more papers by this author First published: 16 January 2016 https://doi.org/10.1111/aji.12475Citations: 3Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Abstract Problem A wide variety of mediators are involved in inflammatory processes. However, the identity of those participating in vaginal immune responses has not been established. We correlated extracellular matrix metalloproteinase inducer (EMMPRIN), matrix metalloproteinase-8 (MMP-8), hyaluronan (HA), hyaluronidase-1 (Hyal-1), human β-defensin-2 (hBD2), and neutrophil gelatinase-associated lipocalin (NGAL) concentrations with the extent of leukocyte infiltration into the vagina and suggest their participation in vaginal inflammation. Methods of study Vaginal fluid was obtained from 233 women seen at the outpatient clinic in the Department of Obstetrics and Gynecology at Campinas University, Brazil. The magnitude of vaginal inflammation was determined by the leukocyte count on vaginal smears and categorized as no inflammation (0 leukocytes/field), moderate inflammation (1–4 leukocytes/field), and intense inflammation (>4 leukocytes/field). Concentrations of EMMPRIN, MMP-8, HA, Hyal-1, hBD2, and NGAL were determined in vaginal fluid by ELISA. Results EMMPRIN, MMP-8, HA, hBD2, and NGAL concentration increased with elevated leukocyte numbers (P < 0.05), while Hyal-1 did not. EMMPRIN concentrations were correlated with HA and MMP-8 levels. Conclusion EMMPRIN, MMP-8, HA, β-defensin, and NGAL are elevated in women with vaginal inflammation. Citing Literature Volume75, Issue2February 2016Pages 126-133 RelatedInformation
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