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Fibronectin Distribution in Normal and Malignant Urothelium

1990; Lippincott Williams & Wilkins; Volume: 143; Issue: 2 Linguagem: Inglês

10.1016/s0022-5347(17)39977-9

1527-3792

H. Barton Grossman, Monica Liebert, Gary Wedemeyer, Glen Wilson, Andrew Flint,

Urologic and reproductive health conditions

No AccessJournal of Urology1 Feb 1990Fibronectin Distribution in Normal and Malignant Urothelium H. Barton Grossman, Monica Liebert, Gary Wedemeyer, Glen Wilson, and Andrew Flint H. Barton GrossmanH. Barton Grossman , Monica LiebertMonica Liebert , Gary WedemeyerGary Wedemeyer , Glen WilsonGlen Wilson , and Andrew FlintAndrew Flint View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)39977-9AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Fibronectin is a glycoprotein that mediates the attachment of BCG to the murine bladder. To assess the potential role of fibronectin on bladder cancer cells as a specific substrate for BCG binding in man, a semi-quantitative method was employed to evaluate the presence of fibronectin on normal urothelium and bladder cancer. Monoclonal anti-fibronectin binding to normal and malignant urothelial tissues was evaluated by an immunoperoxidase assay. Human tumor cell lines were evaluated with mixed hemadsorption and immunoperoxidase assays. In both systems, immunoreactive fibronectin had low expression on unfixed normal and malignant urothelium. With fixation, immunoreactive fibronectin decreased on supporting stroma and increased in normal and malignant urothelium. Fibronectin distribution did not show tumor specificity either with fixed or unfixed specimens. (J. Urol., 143: 418–420, 1990) © 1990 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited ByChen F, Crist S, Zhang G, Iwamoto Y and See W (2018) Interleukin-6 Production by Human Bladder Tumor Cell Lines is Up-Regulated by Bacillus Calmette-Guerin Through Nuclear Factor-κB and Ap-1 Via an Immediate Early PathwayJournal of Urology, VOL. 168, NO. 2, (786-797), Online publication date: 1-Aug-2002.BÖHLE A, JURCZOK A, ARDELT P, WULF T, ULMER A, JOCHAM D and BRANDAU S (2018) INHIBITION OF BLADDER CARCINOMA CELL ADHESION BY OLIGOPEPTIDE COMBINATIONS IN VITRO AND IN VIVOJournal of Urology, VOL. 167, NO. 1, (357-363), Online publication date: 1-Jan-2002.See W, Xu Y, Gee K, Severson C, Cohen M and Ladehoff D (2018) Transurethral Bladder Tumor Resection Alters Fibronectin Expression in Transitional Carcinoma Cell LinesJournal of Urology, VOL. 157, NO. 3, (1136-1143), Online publication date: 1-Mar-1997.Fleischmann J, Park M and Hassan M (2018) Fibronectin Expression on Surgical Specimens Correlated with the Response to Intravesical Bacillus Calmette-Guerin TherapyJournal of Urology, VOL. 149, NO. 2, (268-271), Online publication date: 1-Feb-1993.Garden R, Liu B, Redwood S, Weiss R and Droller M (2018) Bacillus Calmette-Guerin Abrogates in Vitro Invasion and Motility of Human Bladder Tumor Cells via Fibronectin InteractionJournal of Urology, VOL. 148, NO. 3 Part 1, (900-905), Online publication date: 1-Sep-1992. Volume 143Issue 2February 1990Page: 418-420 Advertisement Copyright & Permissions© 1990 by The American Urological Association Education and Research, Inc.MetricsAuthor Information H. Barton Grossman More articles by this author Monica Liebert More articles by this author Gary Wedemeyer More articles by this author Glen Wilson More articles by this author Andrew Flint More articles by this author Expand All Advertisement Loading ...