Artigo Revisado por pares

PROPERTIES OF MAXIMAL SEIZURES, AND THEIR ALTERATION BY ANTICONVULSANT DRUGS AND OTHER AGENTS

1946; American Physiological Society; Volume: 9; Issue: 3 Linguagem: Inglês

10.1152/jn.1946.9.3.231

ISSN

1522-1598

Autores

James E. P. Toman, Ewart A. Swinyard, Laurie Goodman,

Tópico(s)

Computational Drug Discovery Methods

Resumo

ArticlesPROPERTIES OF MAXIMAL SEIZURES, AND THEIR ALTERATION BY ANTICONVULSANT DRUGS AND OTHER AGENTSJames E. P. Toman, Ewart A. Swinyard, and Louis S. GoodmanJames E. P. Toman, Ewart A. Swinyard, and Louis S. GoodmanPublished Online:01 May 1946https://doi.org/10.1152/jn.1946.9.3.231MoreSectionsPDF (2 MB)Download PDF ToolsExport citationAdd to favoritesGet permissionsTrack citations ShareShare onFacebookTwitterLinkedInEmail Previous Back to Top Next FiguresReferencesRelatedInformationCited ByAnticonvulsive properties of soticlestat, a novel cholesterol 24‐hydroxylase inhibitor30 March 2022 | Epilepsia, Vol. 63, No. 6Synthesis, molecular modelling study of the methaqualone analogues as anti-convulsant agent with improved cognition activity and minimized neurotoxicityJournal of Molecular Structure, Vol. 1251O-GlcNAc transferase OGT-1 and the ubiquitin ligase EEL-1 modulate seizure susceptibility in C. elegans19 November 2021 | PLOS ONE, Vol. 16, No. 11Electrical stimulation in animal models of epilepsy: A review on cellular and electrophysiological aspectsLife Sciences, Vol. 285Synthesis of Novel Triazolyl/Oxadiazolyl/Thiadiazolyl-Piperazine as Potential Anticonvulsant Agents12 January 2021 | Drug Research, Vol. 71, No. 04Modelling epilepsy in the mouse: challenges and solutions1 March 2021 | Disease Models & Mechanisms, Vol. 14, No. 3Climate change and epilepsy: Insights from clinical and basic science studiesEpilepsy & Behavior, Vol. 116DESIGN AND SYNTHESIS OF NOVEL TRIAZOLYL/OXADIAZOLYL/ THIADIAZOLYL-CARBAZOLES AS POTENT ANTICONVULSANT AGENTS8 October 2020 | INDIAN DRUGS, Vol. 57, No. 07α-Substituted Lactams and Acetamides: Ion Channel Modulators that Show Promise in Treating Drug-resistant EpilepsyCentral Nervous System Agents in Medicinal Chemistry, Vol. 20, No. 2The anticonvulsant effects of cannabidiol in experimental models of epileptic seizures: From behavior and mechanisms to clinical insightsNeuroscience & Biobehavioral Reviews, Vol. 111SYNTHESIS AND EVALUATION OF SOME NEWER QUINAZOLINONYL SUBSTITUTED BENZOXAZEPINYL / BENZOTHIAZEPINYL INDOLES AS POTENT ANTICONVULSANT AGENTS30 March 2019 | INDIAN DRUGS, Vol. 56, No. 03Non-genetic in vivo experimental models of epilepsy and vagus nerve stimulation1 October 2018 | Translational Medicine, Vol. 5, No. 3SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME NOVEL BENZODIAZEPINE CONTAINING BENZOTHIAZEPINE/BENZOXAZEPINE DERIVATIVES AS POTENT ANTICONVULSANT AGENTS30 June 2018 | INDIAN DRUGS, Vol. 55, No. 06Anticonvulsant effect of the hydroethanolic leaf extract of Psydrax subcordata (DC.) Bridson in murine modelsJournal of Ethnopharmacology, Vol. 213SYNTHESIS OF NOVEL QUINAZOLIN-4(3H)-ONYL AZETIDINONES AS POTENTIAL ANTICONVULSANT AGENTS30 November 2017 | INDIAN DRUGS, Vol. 54, No. 11Multifunctional Hybrid Compounds Derived from 2-(2,5-Dioxopyrrolidin-1-yl)-3-methoxypropanamides with Anticonvulsant and Antinociceptive Properties4 October 2017 | Journal of Medicinal Chemistry, Vol. 60, No. 20Modulating the Serotonin Receptor Spectrum of Pulicatin Natural Products26 July 2017 | Journal of Natural Products, Vol. 80, No. 8Animal Models of Seizures and Epilepsy: Past, Present, and Future Role for the Discovery of Antiseizure Drugs13 March 2017 | Neurochemical Research, Vol. 42, No. 7Synthesis and Anticonvulsant Properties of New 3,3-Diphenyl-2,5-dioxo-pyrrolidin-1-yl-acetamides and 3,3-Diphenyl-propionamides20 March 2017 | Archiv der Pharmazie, Vol. 350, No. 3-4Electrical Stimulation Seizure ModelsDrug development for refractory epilepsy: The past 25 years and beyondSeizure, Vol. 44Fit for purpose application of currently existing animal models in the discovery of novel epilepsy therapiesEpilepsy Research, Vol. 126Modulating Behavior in C. elegans Using Electroshock and Antiepileptic Drugs26 September 2016 | PLOS ONE, Vol. 11, No. 9Design, synthesis and anticonvulsant activity of new hybrid compounds derived from N -phenyl-2-(2,5-dioxopyrrolidin-1-yl)-propanamides and -butanamidesBioorganic & Medicinal Chemistry, Vol. 24, No. 13Synthesis, and anticonvulsant activity of new amides derived from 3-methyl- or 3-ethyl-3-methyl-2,5-dioxo-pyrrolidin-1-yl-acetic acidsBioorganic & Medicinal Chemistry, Vol. 24, No. 8New hybrid molecules with anticonvulsant and antinociceptive activity derived from 3-methyl- or 3,3-dimethyl-1-[1-oxo-1-(4-phenylpiperazin-1-yl)propan-2-yl]pyrrolidine-2,5-dionesBioorganic & Medicinal Chemistry, Vol. 24, No. 4Pyridofuropyrrolo[1,2-a]pyrimidines and pyridofuropyrimido[1,2-a]azepines: new chemical entities (NCE) with anticonvulsive and psychotropic properties1 January 2016 | RSC Advances, Vol. 6, No. 38Pyridofuropyrrolo[1,2-a]pyrimidines and pyridofuropyrimido[1,2-a]azepines: new chemical entities (NCE) with anticonvulsive and psychotropic properties1 January 2016 | RSC Advances, Vol. 6, No. 54Design, synthesis and biological evaluation of new hybrid anticonvulsants derived from N-benzyl-2-(2,5-dioxopyrrolidin-1-yl)propanamide and 2-(2,5-dioxopyrrolidin-1-yl)butanamide derivativesBioorganic & Medicinal Chemistry, Vol. 23, No. 10Current understanding of the mechanism of action of the antiepileptic drug lacosamideEpilepsy Research, Vol. 110Synthesis, Physicochemical, and Anticonvulsant Properties of New N -Mannich Bases Derived from Pyrrolidine-2,5-dione and Its 3-Methyl Analog19 August 2014 | Archiv der Pharmazie, Vol. 347, No. 10Sudden unexpected death in epilepsy: Fatal post-ictal respiratory and arousal mechanismsRespiratory Physiology & Neurobiology, Vol. 189, No. 2New avenues for anti-epileptic drug discovery and development20 September 2013 | Nature Reviews Drug Discovery, Vol. 12, No. 10Synthesis and biological evaluation of some new substituted benzoxazepine and benzothiazepine as antipsychotic as well as anticonvulsant agentsArabian Journal of Chemistry, Vol. 5, No. 3Pharmacological and Toxicological Studies of α-Methyl-α-Phenylglutarimide12 April 2011 | Journal of Pharmacy and Pharmacology, Vol. 7, No. 1Modern antiepileptic drug development has failed to deliver: Ways out of the current dilemma22 March 2011 | Epilepsia, Vol. 52, No. 4Functional, metabolic, and synaptic changes after seizures as potential targets for antiepileptic therapyEpilepsy & Behavior, Vol. 19, No. 2Synthesis and antipsychotic and anticonvulsant activity of some new substituted oxa/thiadiazolylazetidinonyl/thiazolidinonylcarbazolesEuropean Journal of Medicinal Chemistry, Vol. 45, No. 7Effect of repeated administration of Annona diversifolia Saff. (ilama) extracts and palmitone on rat amygdala kindlingEpilepsy & Behavior, Vol. 16, No. 4Anticonvulsant characteristics of pyridoxyl-γ-aminobutyrate, PL-GABANeuropharmacology, Vol. 54, No. 6Effects of Various Antiepileptics on Behavioral and Electroencephalographic Seizures Induced by Maximal Electroshock in MiceJournal of Pharmacological Sciences, Vol. 106, No. 1Influences of Histamine H1 Receptor Antagonists on Maximal Electroshock Seizure in Infant RatsBiological & Pharmaceutical Bulletin, Vol. 30, No. 3Effects of Certain Antiepileptics on Behavioral and Electromyographic Seizure Patterns Induced by Maximal Electroshock in MiceJournal of Pharmacological Sciences, Vol. 104, No. 1Synthesis and anticonvulsant activity of some potential thiazolidinonyl 2-oxo/thiobarbituric acidsEuropean Journal of Medicinal Chemistry, Vol. 41, No. 10Activity of common anticonvulsant drugs on spinal seizure-induced by sudden coolingProgress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 30, No. 7Establishment of Rat Model of Drug-Induced Gingival Overgrowth Induced by Continuous Administration of PhenytoinJournal of Pharmacological Sciences, Vol. 98, No. 3Synthesis and pharmacological evaluation of newer substituted benzoxazepine derivatives as potent anticonvulsant agentsEuropean Journal of Medicinal Chemistry, Vol. 39, No. 4Structural and functional characterization of gastric mucosa and central nervous system in histamine H2 receptor-null miceEuropean Journal of Pharmacology, Vol. 468, No. 1Anticonvulsants15 January 2003Tranquilizing, antihistaminic and purgative activity of Nyctanthes arbor tristis leaf extractJournal of Ethnopharmacology, Vol. 81, No. 3Mouse strain variation in maximal electroshock seizure thresholdBrain Research, Vol. 936, No. 1-2Comparison of the Anticonvulsant Efficacies and Neurotoxic Effects of Valproic Acid, Phenytoin, and the Ketogenic Diet20 December 2001 | Epilepsia, Vol. 42, No. 10Quantitative Genetic Study of Maximal Electroshock Seizure Threshold in Mice: Evidence for a Major Seizure Susceptibility Locus on Distal Chromosome 1Genomics, Vol. 75, No. 1-3In vivo pharmacology of BIIR 561 CL, a novel combined antagonist of AMPA receptors and voltage-dependent Na + channels29 January 2009 | British Journal of Pharmacology, Vol. 133, No. 6A ketogenic diet has different effects upon seizures induced by maximal electroshock and by pentylenetetrazole infusionEpilepsy Research, Vol. 38, No. 2-3Casimiroa edulis seed extracts show anticonvulsive properties in ratsJournal of Ethnopharmacology, Vol. 68, No. 1-3Efficacy of Shitei-To, a Traditional Chinese Medicine Formulation, Against Convulsions in Mice5 April 2012 | The American Journal of Chinese Medicine, Vol. 27, No. 01Zonisamide: Pharmacology and Clinical Efficacy in Epilepsy7 June 2006 | CNS Drug Reviews, Vol. 4, No. 4Effects of repeated seizure induction on seizure activity, post-ictal and interictal behaviorBrain Research, Vol. 814, No. 1-2Pharmacodynamic interaction between phenytoin and sodium valproate changes seizure thresholds and pattern11 February 2009 | British Journal of Pharmacology, Vol. 125, No. 5Electroshock16 December 2009Seizure patterns in kindling and cortical stimulation models of experimental epilepsyBrain Research, Vol. 770, No. 1-2Preclinical characterization of MDL 27,192 as a potential broad spectrum anticonvulsant agent with neuroprotective propertiesEpilepsy Research, Vol. 27, No. 1Synthesis and psychotropic activity of triazoles and tetrazoles condensed with spyro(benzo[h]quinazoline-5,1′-cycloalkanes)Pharmaceutical Chemistry Journal, Vol. 30, No. 8Genetic variation in immediate and delayed postictal refractory period in ratsBrain Research, Vol. 721, No. 1-2Synthesis and biological properties of N-substituted α,β-dehydrodipeptidesPharmaceutical Chemistry Journal, Vol. 29, No. 3Developments in anticonvulsantsEvaluation of the CNS properties of SCH 29851, a potential non-sedating antihistamineAgents and Actions, Vol. 43, No. 3-4Seizure threshold to lidocaine is decreased following repeated ECS (electroconvulsive shock)Psychopharmacology, Vol. 111, No. 4Research on antibacterial and antifungal agents. X. Synthesis and antimicrobial activities of 1-phenyl-2-(1H-azol-1-yl) ethane derivatives. Anticonvulsant activity of 1-(4-methylphenyl)-2-(1H-imidazol-1-yl) ethanolEuropean Journal of Medicinal Chemistry, Vol. 28, No. 10Synthesis and anticonvulsant and anti inflammatory activities of new 3-aryl/alkylimino-1-methylindol-2-onesArchives of Pharmacal Research, Vol. 15, No. 3Neuropsychopharmacological study of 2,4-dihydro[1,2,4] triazolo[3,4-C][1,4]benzothiazine-1-one (IDPH-791)Pharmacological Research, Vol. 26, No. 2MDL 27,531 selectively reverses strychnine-induced seizures in mice19 July 2012 | British Journal of Pharmacology, Vol. 106, No. 4Properties of the convulsive threshold determined by direct cortical stimulation in ratsEpilepsy Research, Vol. 12, No. 2Synthesis and some pharmacological properties of N-benzoyl-α,β-dehydrodipeptidesPharmaceutical Chemistry Journal, Vol. 26, No. 7-8Strategies for identifying and developing new anticonvulsant drugsPharmaceutisch Weekblad Scientific Edition, Vol. 14, No. 3Antikonvulsive 3-Carbamoyl-Isochinolinone: Synthese und Antikonvulsive Aktivität von 3-Carbamoyl-4-Aryl-Isochinolin-1(2H)-onen25 August 2010 | Archiv der Pharmazie, Vol. 324, No. 10The thalamocortical contribution to epilepsyBulletin of Mathematical Biology, Vol. 53, No. 44,4′-dibromobenzylic acid β- and γ-aminoalkyl ester hydrochlorides and their biological propertiesPharmaceutical Chemistry Journal, Vol. 25, No. 4Hydrochlorides of γ-hexamethyleneiminopropyl esters of α-alkoxydiphenylacetic and α-phenylcyclohexylglycolic acids and their pharmacological propertiesPharmaceutical Chemistry Journal, Vol. 24, No. 3Anticonvulsant potency and toxicity of 5,5-diphenyl-2,4-oxazolidinedioneDrug Development Research, Vol. 21, No. 1Pharmacological and Toxicological Evaluation of Potential Antiepileptic Drugs in the Kindling Model of EpilepsyCyclosporine lowers seizure threshold in an experimental model of electroshock-induced seizures in Munich-Wistar ratsLife Sciences, Vol. 46, No. 14Synthesis and anticonvulsant activity of 3-dimethylaminomethyl-8-oxoindeno-[2,1-b]pyrrolesPharmaceutical Chemistry Journal, Vol. 23, No. 12Relationship between Concentration and Anticonvulsant Effect of Phenytoin against Electroshock-Induced Seizures in Rats: Comparison of Sampling Sites for Concentration DeterminationsJournal of Pharmaceutical Sciences, Vol. 78, No. 6Antiepileptic Drug Development Program: A Cooperative Effort of Government and IndustryEpilepsia, Vol. 30, No. s1Pharmacological properties of MDL 19,301: A novel, nonsteroidal, anti-inflammatory agentDrug Development Research, Vol. 16, No. 1Anticonvulsant activity of oxindole derivatives and 1,3-disubstituted indolesPharmaceutical Chemistry Journal, Vol. 22, No. 10Concepts of the Neurophysiological Action of Antiepileptic Drugs10 February 2015 | American Journal of EEG Technology, Vol. 28, No. 3Progression and Generalization of Seizure Discharge: Anatomical and Neurochemical SubstratesEpilepsia, Vol. 29, No. s2Synthesis and pharmacological activity of 3H-[1,4]diazepino-[2,3-g]indolesPharmaceutical Chemistry Journal, Vol. 21, No. 12Brainstem Experimental Seizures Produced by Microinjections of CarbacholEpilepsia, Vol. 28, No. 5Synthesis and biological activity of 3-R-1,2,3,4-tetrahydro-β-carboline derivativesPharmaceutical Chemistry Journal, Vol. 21, No. 6Studies of dosage, seizure threshold, and seizure duration in ECTBiological Psychiatry, Vol. 22, No. 3Synthesis and anticonvulsant activity of oximes of 1-R-3-acetonyl-3-hydroxyoxindole and its derivativesPharmaceutical Chemistry Journal, Vol. 21, No. 2The Role of Neurotransmitters in Electroshock Seizure ModelsOxygen-containing heterocycles. XVII. Synthesis and anticonvulsant activity of cyclic 1,3-benzodioxole-2-carboxy-2-acetic imides and aminesPharmaceutical Chemistry Journal, Vol. 21, No. 1Synthesis and pharmacological properties of 1,2,3-substituted 1,2,3,4-tetrahydro-β-carbolinesPharmaceutical Chemistry Journal, Vol. 20, No. 10Modification of electroshock and pentylenetetrazol seizure patterns in rats affer precollicular transectionsExperimental Neurology, Vol. 93, No. 3Interaction studies in mice of SCH 29851, a potential nonsedating antihistamine, with commonly used therapeutic agentsAgents and Actions, Vol. 18, No. 5-6Characteristics and Mechanisms of Tolerance to BenzodiazepinesVariation in threshold and pattern of electroshock-induced seizures in rats depending on site of stimulationLife Sciences, Vol. 37, No. 23Differential antagonism of denzimol to various components of metrazol-induced seizures in rats and micePharmacological Research Communications, Vol. 17, No. 12Increased anticonvulsant effect of phenobarbital with age in mice ---A possible pharmacological index for brain agingLife Sciences, Vol. 37, No. 15Convulsive thresholds and severity and the anticonvulsant effect of phenobarbital and phenytoin in adult rats administered 6-hydroxydopamine or 5,7-dihydroxytryptamine during postnatal developmentPharmacology Biochemistry and Behavior, Vol. 23, No. 3A timed intravenous pentylenetetrazol infusion scizure model for quantitating the anticonvulsant effect of valproic acid in the ratJournal of Pharmacological Methods, Vol. 13, No. 2AnticonvulsantsHydantoinsBarbituric Acid DerivativesElectrophysiological Effects of Antiepileptic DrugsChemical Constitution and Pharmacological EffectInvolvement of a GABAergic mechanism in the anticonvulsant effect of pentobarbital against maximal electroshock-induced seizures in ratsPharmacology Biochemistry and Behavior, Vol. 22, No. 1Response of rats to seizure stimulus modified by feedingGeneral Pharmacology: The Vascular System, Vol. 16, No. 2CNS Depressant Activity of Cuscuta chinensis Lam27 September 2008 | International Journal of Crude Drug Research, Vol. 23, No. 2Pharmacological study on piperineArchives of Pharmacal Research, Vol. 7, No. 2Kinetics of Drug Action in Disease States III: Effect of Pregnancy on the Relationship between Phenytoin Concentration and Antiseizure Activity in RatsJournal of Pharmaceutical Sciences, Vol. 73, No. 10Evaluation of the CNS properties of SCH 29851, a potential non-sedating antihistamineAgents and Actions, Vol. 14, No. 5-6Synthesis and antispasmodic activity of 2-alkyl substituted thieno[2,3-d]pyrimidin-4-onesPharmaceutical Chemistry Journal, Vol. 18, No. 4Does electroconvulsive therapy cause brain damage?4 February 2010 | Behavioral and Brain Sciences, Vol. 7, No. 1Some perspectives on electroconvulsive therapy4 February 2010 | Behavioral and Brain Sciences, Vol. 7, No. 1ECT: Wanted and unwanted effects4 February 2010 | Behavioral and Brain Sciences, Vol. 7, No. 1Electroshock therapy and brain damage: The acute organic brain syndrome as treatment4 February 2010 | Behavioral and Brain Sciences, Vol. 7, No. 1Possible brain damage by electroconvulsive therapy: Memory impairment and cultural resistance4 February 2010 | Behavioral and Brain Sciences, Vol. 7, No. 1Brain damage from spontaneous but not from induced seizures in animals4 February 2010 | Behavioral and Brain Sciences, Vol. 7, No. 1ECT — verdict: Not guilty4 February 2010 | Behavioral and Brain Sciences, Vol. 7, No. 1An overdue comprehensive look at a maligned treatment: Electroconvulsive therapy4 February 2010 | Behavioral and Brain Sciences, Vol. 7, No. 1Problems in research on electroconvulsive therapy4 February 2010 | Behavioral and Brain Sciences, Vol. 7, No. 1ECT-induced memory impairment – a cholinergic mechanism?4 February 2010 | Behavioral and Brain Sciences, Vol. 7, No. 1After forty-five years ECT is still controversial4 February 2010 | Behavioral and Brain Sciences, Vol. 7, No. 1Modern ECT: Effective and safe4 February 2010 | Behavioral and Brain Sciences, Vol. 7, No. 1Not all seizures are created equal: The importance of ECT dose-response variables4 February 2010 | Behavioral and Brain Sciences, Vol. 7, No. 1Electroconvulsive therapy, pharmacotherapy, and psychotherapy4 February 2010 | Behavioral and Brain Sciences, Vol. 7, No. 1Current issues in ECT practice and research4 February 2010 | Behavioral and Brain Sciences, Vol. 7, No. 1Opinion and facts about ECT: Can science help?4 February 2010 | Behavioral and Brain Sciences, Vol. 7, No. 1ECT: A clinician's viewpoint4 February 2010 | Behavioral and Brain Sciences, Vol. 7, No. 1The justification for electroconvulsive therapy4 February 2010 | Behavioral and Brain Sciences, Vol. 7, No. 1ECT: The controversy continues4 February 2010 | Behavioral and Brain Sciences, Vol. 7, No. 1ECT and brain damage: How much risk is acceptable?4 February 2010 | Behavioral and Brain Sciences, Vol. 7, No. 1ECT damage: Are there more pressing problems?4 February 2010 | Behavioral and Brain Sciences, Vol. 7, No. 1ECT: Out of the shadows and into the light4 February 2010 | Behavioral and Brain Sciences, Vol. 7, No. 1Loss of familiarity as an explanation of autobiographical memory loss4 February 2010 | Behavioral and Brain Sciences, Vol. 7, No. 1ECT: facts, affects, and ambiguities4 February 2010 | Behavioral and Brain Sciences, Vol. 7, No. 1Synthesis and Anticonvulsant Properties of Some 2-Aminoethanesulfonie Acid (Taurine) DerivativesJournal of Pharmaceutical Sciences, Vol. 73, No. 1A Study on CNS Depressant Acitivity of Salvia haematodes Wall27 September 2008 | International Journal of Crude Drug Research, Vol. 22, No. 1Phenytoin: Basic and clinical pharmacologyMedicinal Research Reviews, Vol. 3, No. 4Do different anticonvulsant tests provide the same information concerning the profiles of antiepileptic activity?Pharmacological Research Communications, Vol. 15, No. 8Effects of phenytoin, carbamazepine, and clonazepam on cortex- and amygdala-evoked potentialsExperimental Neurology, Vol. 81, No. 25-p-alkoxyphenyl-5-benzyl- and 5-p-alkoxyphenyl-5-phenylhydantoins and their sodium saltsPharmaceutical Chemistry Journal, Vol. 17, No. 7Anticonvulsant activity of some 2-aminoethanesulphonic acid (taurine) derivativesEuropean Journal of Pharmacology, Vol. 87, No. 2-3Anticonvulsant activity of 2-phthalimidoethanesulphonamides: New derivatives of taurineNeurochemistry International, Vol. 5, No. 3Hippocampal neuron loss in epilepsy and after experimental seizuresActa Neurologica Scandinavica, Vol. 66, No. 6Dose-Response Analysis of Phenytoin on Electrically Induced Seizures and Spontaneous Activity of Cerebellar Purkinje Cells in the FrogEpilepsia, Vol. 23, No. 2Synthesis and biological activity of esters and hydrazides of phosphorylated phenylacetic acidsPharmaceutical Chemistry Journal, Vol. 16, No. 3Anticonvulsant structure-activity relationships: Historical development and probable causes of failureDrug Development Research, Vol. 2, No. 4Enhancement of cortical evoked potentials by high atmospheric pressures of heliumBrain Research Bulletin, Vol. 7, No. 4Antagonism of Experimentally Induced Tonic Seizures Following a Lesion in the Midbrain TegmentumEpilepsia, Vol. 22, No. 5Cellular compartments of GABA in brain and their relationship to anticonvulsant activityMolecular and Cellular Biochemistry, Vol. 39, No. 1Studies on the post-ictal rise in seizure thresholdEuropean Journal of Pharmacology, Vol. 71, No. 2-3Cellular compartments of GABA in brain and their relationship to anticonvulsant activityEPILEPTOGENESIS AND THALAMOCORTICAL NEURONSNeuropharmacological analysis of handling-induced seizures in gerbilsNeuropharmacology, Vol. 19, No. 10Resistance to Tonic-Clonic seizures after amygdaloid kindling in catsExperimental Neurology, Vol. 69, No. 2Protection from shock-induced seizures as a measure of hypnotic potency of drugsPharmacology Biochemistry and Behavior, Vol. 13, No. 2Synthesis and neurotropic activity of N-(D-homopantothenoyl)-N,N′-dicyclohexylureaPharmaceutical Chemistry Journal, Vol. 14, No. 8Interaction of diphenylhydantoin and benzodiazepines in the CNSBrain Research, Vol. 189, No. 1The Development of Tolerance to the Anticonvulsant Effect of Phenobarbital in MiceEpilepsia, Vol. 21, No. 2Synthesis and anticonvulsive activity of alkyl esters of 5-substituted 2-sulfamoylbenzoic acidsPharmaceutical Chemistry Journal, Vol. 14, No. 2NeoplasmsRelationships Between Plasma Concentrations of Diphenylhydantoin, Phenobarbital, Carbamazepine, and 3-Sulfamoylmethyl-1,2-Benzisoxazole (AD-810), a New Anticonvulsant Agent, and Their Anticonvulsant or Neurotoxic Effects in Experimental AnimalsEpilepsia, Vol. 20, No. 6Evidence against serotonin involvement in the tonic component of electrically induced convulsions and in carbamazepine anticonvulsant activityPsychopharmacology, Vol. 66, No. 1Neurotropic and anti-inflammatory action of thioestersPharmaceutical Chemistry Journal, Vol. 13, No. 5Saccharin derivativesPharmaceutical Chemistry Journal, Vol. 13, No. 2Effect of drugs modifying central serotonergic function on the response of extensor and nonextensor rats to maximal electroshockLife Sciences, Vol. 23, No. 24Effects of Antiepileptics on Both Behavioral and Electrographic Seizure Patterns Induced by Maximal Electroshock in RatsEpilepsia, Vol. 19, No. 6Synthesis and biological properties of 1,4-substituted thiosemicarbazides and 1,2,4-triazolesPharmaceutical Chemistry Journal, Vol. 12, No. 11Neurotropic activity of di-(α-carbalkoxymethoxy)-diethylsilanes and carbalkoxyalkyl(aryl)-oxytrialkylsilanesPharmaceutical Chemistry Journal, Vol. 12, No. 10Effects of intraventricularly administered monoamines on seizure susceptibility and body temperature in ratsNeuropharmacology, Vol. 17, No. 8Prostaglandin El-induced potentiation of the anticonvulsant action of phenobarbitone in the rat. Role of brain monoamines.Prostaglandins and Medicine, Vol. 1, No. 25-p-Alkoxyphenyl- and 5-(p-alkoxyphenyl)-5-methylhydantoinsPharmaceutical Chemistry Journal, Vol. 12, No. 8Effect of intracisternal 6-hydroxydopamine on seizure susceptibility in ratsEuropean Journal of Pharmacology, Vol. 50, No. 2Effects of intracerebroventricular administration of PGE1, E2 and F2α on electrically induced convulsions in miceProstaglandins, Vol. 15, No. 6CHANGES IN SEIZURE SUSCEPTIBILITY AFTER INTRACEREBRAL TREATMENT WITH 5,7-DIHYDROXYTRYPTAMINE: ROLE OF SEROTONERGIC NEURONSAnnals of the New York Academy of Sciences, Vol. 305, No. 1 Serotonin NeuAntiextensor effects of 3,3-diphenyl-n-propylamine in the mouseEuropean Journal of Pharmacology, Vol. 48, No. 3Synthesis and biological activity of hydrazides of phosphorylated carboxylic acidsPharmaceutical Chemistry Journal, Vol. 12, No. 4The Pharmacology of Silanes and SiloxanesAnticonvulsant action of cannabis in the rat: Role of brain monoaminesPsychopharmacology, Vol. 59, No. 3ANTI-CONVULSANT EFFECT OF PHTHALAZINO-2,3b-PHTHALAZINE-5(14H),12(7H)-DIONE (L-5418). I. BEHAVIORAL EFFECTJapanese Journal of Pharmacology, Vol. 28, No. 1Psychotropic and anticonvulsive properties of some benzofuran derivativesPharmaceutical Chemistry Journal, Vol. 11, No. 12Imidazole derivatives. XIII. Synthesis and pharmacological activity of some 1,4,5-substituted 1H-imidazolesPharmaceutical Chemistry Journal, Vol. 11, No. 10Synthesis and anticonvulsive activity of derivatives of condensed 1,4-diazepine systemsPharmaceutical Chemistry Journal, Vol. 11, No. 10The relationship between magnitude of electroshock stimulation and the effects of digitoxigenin, pentylenetetrazol and brain monoamine reduction on electroshock convulsive thresholdsNeuropharmacology, Vol. 16, No. 9Synthesis and antispasmodic activity of 4-alkyl(aryl)amino-6,6-dimethyl-5,6-dihydro-8H-pyrano(thiopyrano) [3.4-b]thieno[5.4-d]-pyrimidinesPharmaceutical Chemistry Journal, Vol. 11, No. 9Synthesis and anticonvulsive activity of 2,3-disubstituted 5,5-dimethyltetrahydropyrano- and 5,5-dimethyltetrahydrothiopyrano [3,4-b]thiophenesPharmaceutical Chemistry Journal, Vol. 11, No. 8Studies on the contribution of active metabolites to the anticonvulsant effects of propranololEuropean Journal of Pharmacology, Vol. 42, No. 1Postseizure inhibition of kindled seizuresExperimental Neurology, Vol. 54, No. 2Experimental Evaluation of AnticonvulsantsNoncyclic AnticonvulsantsBlockade of the Tonic Hindlimb Extensor Component of Maximal Electroshock and Pentylenetetrazol-Induced Seizures by Drugs Acting on Muscle and Muscle Spindle Systems: A Perspective on MethodEpilepsia, Vol. 17, No. 4Effects of diphenylhydantoin and diazepam on hippocampal evoked responsesNeuropharmacology, Vol. 15, No. 3A comparison of the central actions of prostaglandins A1, E1, E2, F1?, and F2? in the ratPsychopharmacology, Vol. 50, No. 1Research in the 4(3n)-quinazolone series VIII. Synthesis of 2-acyloxymethyl-3-R-4(3n)-quinazolinesPharmaceutical Chemistry Journal, Vol. 9, No. 1Activity of alpha and gamma extensor motor axons during metrazol-induced seizures in catExperimental Neurology, Vol. 43, No. 1Synthesis and peoperties of arylamides of N-anisoylanthranilic acidPharmaceutical Chemistry Journal, Vol. 7, No. 56-(4-methyl-1-piperazinyl)morphanthridine (perlapine), a new tricyclic compound with sedative and sleep-promoting propertiesPsychopharmacologia, Vol. 28, No. 4Tolerance to drum stress and its relationship to dopamine turnoverEuropean Journal of Pharmacology, Vol. 17, No. 2A comparative study of the behavioral effects of scopolamine and 4-(1-naphthylvinyl) pyridine hydrochloride (NVP), an inhibitor of choline acetyltransferasePsychopharmacologia, Vol. 23, No. 1Pharmacological and Biochemical Studies on 2-Amino-4-phenylsulphonylbenzenesulphonamide (NSD 3004): A New Sulphonamide with Anticonvulsant and Carbonic Anhydrase Inhibitory Properties13 March 2009 | Acta Pharmacologica et Toxicologica, Vol. 30, No. 1-2Studies on the functional significance of carbonic anhydrase in central nervous systemBrain Research, Vol. 31, No. 1Maturation of convulsogenic activity induced by leptazol in the albino rat19 July 2012 | British Journal of Pharmacology, Vol. 42, No. 1Effect of diphenylhydantoin on protein metabolism in the central nervous systemExperimental Neurology, Vol. 31, No. 1Effects of chlorpromazine on convulsive responses in developing ratsExperimental Neurology, Vol. 29, No. 3Effect of α-methyltyrosine on stress-induced changes in seizure susceptibilityEuropean Journal of Pharmacology, Vol. 9, No. 2Effects of Tetanization on Transmitter DynamicsEpilepsia, Vol. 10, No. 2Effects of Anticonvulsant Drugs on Nerve TerminalsEpilepsia, Vol. 10, No. 2Laboratory Evaluation of Antiepileptic DrugsEpilepsia, Vol. 10, No. 2Effect of drum stress on maximal electroconvulsive seizure latency in miceInternational Journal of Neuropharmacology, Vol. 8, No. 2Effects of frontal brain electroshock stimulation on eeg activity and memory in rats: Relationship to ECS-produced retrograde amnesiaJournal of Neurobiology, Vol. 1, No. 4Sensitivity of chick embryos to chlorpromazineBrain Research, Vol. 12, No. 1ELECTROSHOCK-INDUCED SEIZURES AND THE TURNOVER OF BRAIN PROTEIN IN THE RATJournal of Neurochemistry, Vol. 15, No. 12Comparative amnesic effects of transcorneal and transpinnate ECS in micePhysiology & Behavior, Vol. 3, No. 6Structure-Activity Relationships Among Some Selected Substituted CyanoacetamidesJournal of Pharmaceutical Sciences, Vol. 57, No. 9Stereoisomerism and pharmacological activity of alkyl-and alkoxyalkyl-substituted 1,3-dioxanesPharmaceutical Chemistry Journal, Vol. 2, No. 9The effect of diphenylhydantoin on sleep in the catElectroencephalography and Clinical Neurophysiology, Vol. 24, No. 5Synthesis of Derivatives of N-Methyl-2-phenylsuccinimide Involving a Lithium Salt Condensation and a Novel Application of the Mannich ReactionJournal of Pharmaceutical Sciences, Vol. 57, No. 3Synthesis and neurotropic activity in the series of 4-alkyl-substituted pyrazolesPharmaceutical Chemistry Journal, Vol. 2, No. 2Motor convulsions and EEG during maximal electroshock in the ratInternational Journal of Neuropharmacology, Vol. 6, No. 3Influence of Hormones on Brain ActivityDrugs and Retrograde AmnesiaConvulsive responses in prenatally irradiated ratsExperimental Neurology, Vol. 16, No. 1Elevation of γ-aminobutyric acid in brain with amino-oxyacetic acid and susceptibility to convulsive seizures in mice: A quantitative re-evaluationBiochemical Pharmacology, Vol. 15, No. 3Comparative studies on the distribution and metabolic fate of diphenylhydantoin and 3-ethoxycarbonyldiphenylhydantoin (P-6127) after chronic administrations to dogs and catsNaunyn-Schmiedebergs Archiv f�r Pharmakologie und Experimentelle Pathologie, Vol. 254, No. 5Pharmacological Evaluation of a Series of 3,6-Substituted Pyridazine DerivativesJournal of Pharmaceutical Sciences, Vol. 54, No. 11The pharmacological properties of a potent neurotropic compound from the dibenzothiazepine groupInternational Journal of Neuropharmacology, Vol. 4, No. 6Spinal Cord Convulsions in the Developing Rat at Altitude (12,470 ft., 3,800 m)Nature, Vol. 207, No. 4994General Anesthetic and Other Pharmacological Properties of 2-(O-Chlorophenyl)-2-Methylamino Cyclohexanone HCl (CI-581)11 March 2013 | The Journal of New Drugs, Vol. 5, No. 1REFERENCESRadiosensitivity of the Ageing BrainNature, Vol. 202, No. 4938The anticonvulsant activity of some tetrazole derivativesToxicology and Applied Pharmacology, Vol. 6, No. 1AnticonvulsantsAnticonvulsant Activity and Toxicity of Phensuximide, Methsuximide and EthosuximideEpilepsia, Vol. 4, No. 1-4Light deprivation as a means of lowering electroshock thresholds in rabbitsExperimental Neurology, Vol. 8, No. 1The entry, accumulation and binding of diphenylhydantoin-2-C14 in brain Studies on adult, immature and hypercapnic catsInternational Journal of Neuropharmacology, Vol. 2, No. 1-2Effect of Œstradiol on Spinal Cord Convulsions in Developing RatsNature, Vol. 197, No. 4870Changes in electroshock convulsive response with repeated seizuresExperimental Neurology, Vol. 7, No. 26 Anticonvulsant DrugsSTRUCTURE AND ACTIVITY RELATIONSHIP OF MONOAMINE OXIDASE INHIBITORS, PHENYLACETYLHYDRAZIDE DERIVATIVESJapanese Journal of Pharmacology, Vol. 13, No. 2Spinal Cord Convulsions in Developing RatsScience, Vol. 137, No. 3529Antagonism of Pentobarbitone Anæsthesia in Hamsters by 5,5-Diphenylhydantoin Modified by SalicylateNature, Vol. 194, No. 4832The Effects of Electroshock on the Acid-soluble Phosphates of Rat BrainJournal of Biological Chemistry, Vol. 237, No. 4The Anticonvulsant Activity of 1,2,4-TriazolesJournal of Medicinal and Pharmaceutical Chemistry, Vol. 5, No. 2TRANSAMINASE ACTIVITY OF NATURALLY OCCURRING INHIBITORY SUBSTANCES AND EFFECTS OF SOME DRUGSJapanese Journal of Pharmacology, Vol. 11, No. 2EFFECTS OF SOME DRUGS ON THE γ-AMINOBUTYRIC ACID TRANSAMINASE AND THE SUCCINIC SEMIALDEHYDE DEHYDROGENASE OF RAT BRAINJapanese Journal of Pharmacology, Vol. 11, No. 1Pharmacologic and toxicologic studies with 2-amino-5-phenyl-1,3,4-oxadiazole hydrochlorideToxicology and Applied Pharmacology, Vol. 3, No. 6Reduction of Tetramine Toxicity by Sedatives and AnticonvulsantsJournal of Pharmaceutical Sciences, Vol. 50, No. 10Postictal hyperexcitability in experimental convulsionsExperimental Neurology, Vol. 4, No. 3Pharmacology of 3,5-Diphenyl-1,2,4-triazoleJournal of Pharmaceutical Sciences, Vol. 50, No. 7The comparative anticonvulsant activity of phenothiazine derivatives in experimental electrical shockBulletin of Experimental Biology and Medicine, Vol. 51, No. 2�ber die antikonvulsive Wirkung der Nicotins�ure im TierversuchKlinische Wochenschrift, Vol. 39, No. 11Spinal Reflexes and Seizure Patterns in the Two-Toed SlothScience, Vol. 133, No. 3462Sex and Strain Differences in Electroshock Convulsions of the RatNature, Vol. 190, No. 4775EFFECT OF LIDOCAINE ON THE SEIZURE DISCHARGE IN ELECTROCONVULSIVE THERAPYActa Psychiatrica Scandinavica, Vol. 35, No. S145EFFECT OF LIDOCAINE AND PROCAINE ON THE ELECTROSHOCK SEIZURE THRESHOLDActa Psychiatrica Scandinavica, Vol. 35, No. S145Some neuropharmacologic effects of four mephenesin-like agents in miceToxicology and Applied Pharmacology, Vol. 2, No. 3Die Behandlung der EpilepsienANTICONVULSANT PROPERTIES OF MONOAMINE OXIDASE INHIBITORS15 December 2006 | Annals of the New York Academy of Sciences, Vol. 80, No. 3Pharmacologic and toxicopathologic studies of 1-methyl-5-phenylpyrazolidin-3-one (U-6373)Toxicology and Applied Pharmacology, Vol. 1, No. 4An anticonvulsant effect of monoamine oxidase inhibitorsExperientia, Vol. 15, No. 4Die Wirkung von Diphenylhydantoin auf die Krampferregbarkeit der HirnrindeZeitschrift für Die Gesamte Experimentelle Medizin, Vol. 129, No. 1Grundlagenuntersuchungen zur Methode fortlaufender Krampferregbarkeitsmessungen an der HirnrindeZeitschrift für Die Gesamte Experimentelle Medizin, Vol. 128, No. 3A GROUP OF COMPOUNDS POSSESSING ANTICONVULSANT ACTIVITY IN THE MAXIMAL ELECTROSHOCK SEIZURE TESTJapanese Journal of Pharmacology, Vol. 6, No. 2USE OF INTRACEREBRAL ELECTRODES TO EVALUATE DRUGS THAT ACT ON THE CENTRAL NERVOUS SYSTEMAnnals of the New York Academy of Sciences, Vol. 64, No. 4Central Depressant Properties of Uracil and Related OxypyrimidinesJournal of the American Pharmaceutical Association (Scientific ed.), Vol. 44, No. 1PiperazinesJournal of the American Pharmaceutical Association (Scientific ed.), Vol. 43, No. 10Electroencephalographic studies, induced seizures, and their modification by phenobarbital, dilantin, and phenurone, in the salamanders, triturus viridescens and ambystoma tigrinumElectroencephalography and Clinical Neurophysiology, Vol. 6Properties and Alterations of Electrically-Induced Seizures in MiceEpilepsia, Vol. C2, No. 1A Note on the Effect of Cortisone and Desoxycorticosterone on Metrazol Convulsions in Mice*,†Journal of the American Pharmaceutical Association (Scientific ed.), Vol. 42, No. 7THE EVALUATION OF “MYSOLINE”-A NEW ANTICONVULSANT DRUG19 July 2012 | British Journal of Pharmacology and Chemotherapy, Vol. 8, No. 2The Significance of Brain Acetylcholine8 February 2018 | Journal of Mental Science, Vol. 99, No. 415THE DRUG TREATMENT OF EPILEPSY1 April 1953 | Medical Journal of Australia, Vol. 1, No. 14STUDIES ON THE EFFECT OF ANTICONVULSANTS ON THE ELECTROSHOCK SEIZURE INDUCED THROUGH CONDENSER DISCHARGE METHODPsychiatry and Clinical Neurosciences, Vol. 6, No. 4THE LOCALIZATION OF THE CENTER DEALING WITH THE TONIC EXTENSOR SEIZURE OF ELECTROSHOCKJapanese Journal of Pharmacology, Vol. 3, No. 1The Anticonvulsant Activity and Toxicity of Methylparafynol (Dormison®) and Some Other AlcoholsScience, Vol. 116, No. 3024Carbon Dioxide Accumulation and Oxygen Depletion as Limiting Factors In Convulsive ActivityActa Physiologica Scandinavica, Vol. 25, No. 1Glutamic Acid and Glucose As Substrates for Mammalian Brain8 February 2018 | Journal of Mental Science, Vol. 97, No. 409Laboratory assay of clinically effective antiepileptic drugs*,††This investigation was supported from the Division of Research Grants and Fellowships of the National Institute of Health, U. S. Public Health Service.Journal of the American Pharmaceutical Association (Scientific ed.), Vol. 38, No. 4The neuropharmacology of antiepilepticsElectroencephalography and Clinical Neurophysiology, Vol. 1, No. 1-4The anticonvulsant properties of tridioneThe American Journal of Medicine, Vol. 1, No. 3 More from this issue > Volume 9Issue 3May 1946Pages 231-239 https://doi.org/10.1152/jn.1946.9.3.231PubMed21028165History Published online 1 May 1946 Published in print 1 May 1946 PDF download Metrics Downloaded 282 times

Referência(s)