Evidence for Urothelial Cell Activation in Interstitial Cystitis
1993; Lippincott Williams & Wilkins; Volume: 149; Issue: 3 Linguagem: Inglês
10.1016/s0022-5347(17)36121-9
ISSN1527-3792
AutoresMonica Liebert, Gary Wedemeyer, Judith A. Stein, Raymond Washington, Gary J. Faerber, Andrew Flint, H. Barton Grossman,
Tópico(s)Urological Disorders and Treatments
ResumoNo AccessJournal of Urology1 Mar 1993Evidence for Urothelial Cell Activation in Interstitial Cystitis Monica Liebert, Gary Wedemeyer, Judith A. Stein, Raymond Washington, Gary Faerber, Andrew Flint, and H. Barton Grossman Monica LiebertMonica Liebert , Gary WedemeyerGary Wedemeyer , Judith A. SteinJudith A. Stein , Raymond WashingtonRaymond Washington , Gary FaerberGary Faerber , Andrew FlintAndrew Flint , and H. Barton GrossmanH. Barton Grossman View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)36121-9AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Bladder biopsy samples from 17 interstitial cystitis patients and 20 controls were evaluated for urothelial cell activation using a panel of monoclonal antibodies to HLA-DR, intercellular adhesion molecule 1, interleukin 1 α and tumor necrosis factor α. Urothelial cells in the majority (13 of 16, 81%) of the biopsies from patients with interstitial cystitis showed increased expression of HLA- DR, while fewer samples were positive for intercellular adhesion molecule 1 (3 of 16, 19%), interleukin 1 α (2 of 17, 12%) or tumor necrosis factor α (1 of 15, 7%). No urothelial cell expression of intercellular adhesion molecule 1, interleukin 1 α or tumor necrosis factor α was detected in the controls, and only 1 of 20 control samples contained HLA-DR positive urothelial cells. These results suggest that an unusual type of cellular activation is present in interstitial cystitis. In vitro studies with cultured normal urothelial cells indicated that cells activated with γ interferon and tumor necrosis factor α expressed intercellular adhesion molecule 1 and HLA-DR, although increases in intercellular adhesion molecule 1 expression occurred earlier. Urothelial cells in interstitial cystitis patients may be defective in ability to express intercellular adhesion molecule 1. Alternatively, the differential expression of HLA-DR and intercellular adhesion molecule 1 in interstitial cystitis specimens may represent a functional subset of interstitial cystitis or reflect different stages of the disease. Urothelial cell activation in interstitial cystitis may result in aberrant immune responses and immune activation within the bladder. Because HLA-DR can be detected in paraffin-embedded tissues, evaluation of urothelial cell HLA-DR expression, although not specific for interstitial cystitis, may become a useful tool in the pathological evaluation of biopsy tissues from patients with this disease. © 1993 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited byBlalock E, Korrect G, Stromberg A and Erickson D (2011) Gene Expression Analysis of Urine Sediment: Evaluation for Potential Noninvasive Markers of Interstitial Cystitis/Bladder Pain SyndromeJournal of Urology, VOL. 187, NO. 2, (725-732), Online publication date: 1-Feb-2012.Yang C, Burks D, Propert K, Mayer R, Peters K, Nickel J, Payne C, FitzGerald M, Hanno P, Chai T, Kreder K, Lukacz E, Foster H, Cen L, Landis J, Kusek J and Nyberg L (2011) Early Termination of a Trial of Mycophenolate Mofetil for Treatment of Interstitial Cystitis/Painful Bladder Syndrome: Lessons LearnedJournal of Urology, VOL. 185, NO. 3, (901-906), Online publication date: 1-Mar-2011.Boucher W, Stern J, Kotsinyan V, Kempuraj D, Papaliodis D, Cohen M and Theoharides T (2008) Intravesical Nanocrystalline Silver Decreases Experimental Bladder InflammationJournal of Urology, VOL. 179, NO. 4, (1598-1602), Online publication date: 1-Apr-2008.Harvey R, Skennerton D, Newgreen D and Fry C (2018) The Contractile Potency of Adenosine Triphosphate and Ecto-adenosine Triphosphatase Activity in Guinea Pig Detrusor and Detrusor From Patients With a Stable, Unstable or Obstructed BladderJournal of Urology, VOL. 168, NO. 3, (1235-1239), Online publication date: 1-Sep-2002.Batler R, Sengupta S, Forrestal S, Schaeffer A and Klumpp D (2018) Mast Cell Activation Triggers a Urothelial Inflammatory Response Mediated by Tumor Necrosis Factor-αJournal of Urology, VOL. 168, NO. 2, (819-825), Online publication date: 1-Aug-2002.Sadhukhan P, Tchetgen M, Rackley R, Vasavada S, Liou L and Bandyopadhyay S (2018) Sodium Pentosan Polysulfate Reduces Urothelial Responses to Inflammatory Stimuli Via an Indirect MechanismJournal of Urology, VOL. 168, NO. 1, (289-292), Online publication date: 1-Jul-2002.BARBALIAS G, LIATSIKOS E, ATHANASOPOULOS A and NIKIFORIDIS G (2018) INTERSTITIAL CYSTITIS: BLADDER TRAINING WITH INTRAVESICAL OXYBUTYNINJournal of Urology, VOL. 163, NO. 6, (1818-1822), Online publication date: 1-Jun-2000.ABDEL-MAGEED A and GHONIEM G (2018) POTENTIAL ROLE OF REL/NUCLEAR FACTOR-kappa B IN THE PATHOGENESIS OF INTERSTITIAL CYSTITISJournal of Urology, VOL. 160, NO. 6 Part 1, (2000-2003), Online publication date: 1-Dec-1998.PETERS K, DIOKNO A, STEINERT B and GONZALEZ J (2018) THE EFFICACY OF INTRAVESICAL BACILLUS CALMETTE-GUERIN IN THE TREATMENT OF INTERSTITIAL CYSTITIS: LONG-TERM FOLLOWUPJournal of Urology, VOL. 159, NO. 5, (1483-1487), Online publication date: 1-May-1998.Keay S, Zhang C, Kagen D, Hise M, Jacobs S, Hebel J, Gordon D, Whitmore K, Bodison S and Warren J (2018) CONCENTRATIONS OF SPECIFIC EPITHELIAL GROWTH FACTORS IN THE URINE OF INTERSTITIAL CYSTITIS PATIENTS AND CONTROLSJournal of Urology, VOL. 158, NO. 5, (1983-1988), Online publication date: 1-Nov-1997.Erickson D, Belchis D and Dabbs D (2018) Inflammatory Cell Types and Clinical Features of Interstitial CystitisJournal of Urology, VOL. 158, NO. 3, (790-793), Online publication date: 1-Sep-1997.Peters K, Diokno A, Steinert B, Yuhico M, Mitchell B, Krohta S, Gillette B and Gonzalez J (2018) The Efficacy of Intravesical Tice Strain Bacillus Calmette-Guerin in the Treatment of Interstitial Cystitis: A Double-Blind, Prospective, Placebo Controlled TrialJournal of Urology, VOL. 157, NO. 6, (2090-2094), Online publication date: 1-Jun-1997.Saban R, Haak-Frendscho M, Zine M, Presta L, Bjorling D and Jardieu P (2018) Human Anti-IgE Monoclonal Antibody Blocks Passive Sensitization of Human and Rhesus Monkey BladderJournal of Urology, VOL. 157, NO. 2, (689-693), Online publication date: 1-Feb-1997.Lotz M, Villiger P, Hugli T, Koziol J and Zuraw B (2018) Interleukin-6 and Interstitial CystitisJournal of Urology, VOL. 152, NO. 3, (869-873), Online publication date: 1-Sep-1994.Felsen D, Frye S, Trimble L, Bavendam T, Lowell Parsons C, Sim Y and Darracott Vaughan E (2018) Inflammatory Mediator Profile in Urine and Bladder Wash Fluid of Patients with Interstitial CystitisJournal of Urology, VOL. 152, NO. 2 Part 1, (355-361), Online publication date: 1-Aug-1994. Volume 149Issue 3March 1993Page: 470-475 Advertisement Copyright & Permissions© 1993 by The American Urological Association Education and Research, Inc.KeywordscystitisbladderHLA-DR antigensMetricsAuthor Information Monica Liebert More articles by this author Gary Wedemeyer More articles by this author Judith A. Stein More articles by this author Raymond Washington More articles by this author Gary Faerber More articles by this author Andrew Flint More articles by this author H. Barton Grossman More articles by this author Expand All Advertisement PDF downloadLoading ...
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