Renin stimulation by passive tilting: The influence of an anti-gravity suit on postural changes in plasma renin activity, plasma noradrenaline concentration and kidney function in normal man
1978; Taylor & Francis; Volume: 38; Issue: 2 Linguagem: Inglês
10.1080/00365517809156085
ISSN1502-7686
AutoresBirger Hesse, Helmer Ring‐Larsen, Ingolf Nielsen, Niels Juel Christensen,
Tópico(s)Cardiovascular and Diving-Related Complications
ResumoPlasma renin activity (PRA), plasma noradrenaline concentration, heart rate, blood pressure, and clearances of para-aminohippurate and inulin were measured in twelve normal subjects (clearances in only three subjects) before and after 40 min of 60 degrees upright tilting. The tilting experiments were repeated after inflation of an anti-gravity suit to 60 mmHg on the lower extremities. Inflation of the anti-gravity suit caused an abolition of the postural PRA increase, a marked reduction of the postural increases in plasma noradrenaline and heart rate, and elimination of the decreases in pulse pressure, inulin and para-aminohippurate clearances and sodium excretion. The results suggest a decisive role of the sympathetic nervous system for postural renin increase, probably mainly activated by stretch receptors in the low-pressure cardiopulmoanry area.
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