THE EFFECT OF TRI‐POTASSIUM DI‐CITRATO BISMUTHATE (DE‐NOL) ON THE HEALING OF CHRONIC DUODENAL ULCERS
1977; Wiley; Volume: 1; Issue: 9 Linguagem: Inglês
10.5694/j.1326-5377.1977.tb130705.x
ISSN1326-5377
AutoresG. P. Coughlin, Ann Kupa, M. H.,
Tópico(s)Gastrointestinal motility and disorders
ResumoForty-six patients suffering from chronic duodenal ulcer, proven endoscopically, were treated in a randomized double-blind cross-over trial with either tri-potassium di-citrato bismuthate (De-Nol) or placebo for four weeks and assessed symptomatically and endoscopically. Those patients who failed to heal after treatment with either agent were crossed over to the alternative preparation and reassessed after a further 28 days. Forty-two patients completed the study involving 57 patient treatments. A highly significant improvement in both symptomatic response (P$lt0$md01) and endoscopic healing (P$lt0$md01) was seen in those patients receiving tri-potassium di-citrato bismuthate (De-Nol) as against placebo therapy.
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