Age-related decline of cerebral oxygen metabolism in normal population detected with positron emission tomography
1992; Taylor & Francis; Volume: 14; Issue: 2 Linguagem: Inglês
10.1080/01616412.1992.11740031
ISSN1743-1328
AutoresHiroto Takada, Ken Nagata, Yutaka Hirata, Yuichi Satoh, Yasuhito Watahiki, Junya Sugawara, Eriko Yokoyama, Yasushi Kondoh, F Shishido, A Inugami, Hideaki Fujita, Toshihide Ogawa, Matsutaro Murakami, Hidehiro lida, lwao Kanno,
Tópico(s)Cerebrovascular and Carotid Artery Diseases
ResumoAbstractAbstractUsing positron emission tomography (PET), cerebral blood flow (CBF) and cerebral metabolic rate of oxygen (CMR02) were measured in 32 healthy volunteers aged from 27 to 67 years. In bilateral putamen, left supratemporal\ left infrafrontal and left parietal cortices, CMR02 showed a significant decline during aging. The age-related decline of CBF was seen only at the left superior temporal cortex. The mean CMR02 was significantly lower in the elder group (over 51 years old) than in the younger group (under 50 years old), whereas no significant difference in mean CBF between the two groups. The poor correlation of CBF to the age could be explained partly by the fact that CBF is easily influenced by the physiological, psychological and/or environmental factors. The age-related changes of CMR02 were more marked in the association cortices of the left hemisphere than in that of the right hemisphere.Key Words:: Positron emission tomographycerebral oxygen metabolism
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