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The Immune Compromised Host

1983; Elsevier BV; Volume: 30; Issue: 1 Linguagem: Inglês

10.1016/s0031-3955(16)34324-3

1557-8240

Walter T. Hughes, Haysam Tufenkeji, Douglas L. Bartley,

Hematological disorders and diagnostics

This chapter deals with the implications of use of cytostatics and immunosuppressive drugs. The cardiotoxic effects of cytostatics should be borne in mind whenever a patient develops a cardiac disorder during and/or following chemotherapy. It is, however, not always easy to distinguish them from (1) preexisting heart disease, (2) involvement of the heart or pericardium by the tumor, (3) nonbacterial thrombotic endocarditis, (4) infectious complications of therapy affecting the heart, and (5) complications of radiotherapy. These other factors can moreover accentuate the cardiotoxic effects of some cytostatics. The chapter also provides a summary of side effects, which have been reported of a number of less-known or experimental agents during the period under review. Skin changes in patients receiving cytotoxic drugs may have a variety of causes. Direct toxic effects of the agent on skin and cutaneous appendages cause the most frequent and clinically distinctive reactions.