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BIBTEX RIS

Studies on lankacidin-group (T-2636) antibiotics. IX. Preparation of 14C-labeled lankacidin C 14-proplonate.

1975; Springer Nature; Volume: 28; Issue: 1 Linguagem: Inglês

10.7164/antibiotics.28.15

ISSN

1881-1469

Autores

Kazunori Hatano, SETSUO HARADA, Toyokazu Kishi,

Tópico(s)

Cancer therapeutics and mechanisms

Resumo

To investigate the metabolic fate of lankacidin C 14-propionate in experimental animals, the 14-C-labeled antibiotic was prepared by the fermentation of Streptomyces rochei var, volubilis in the presence of various 14-C-labeled organic carboxylic acids, amino acids and carbohydrates. Significant incorporation (20 similar to 40%) was observed with L-methionine-methyl-14-C. Lankacidin C 14-propionate-14-C (specific activity 49.6 muCi/mg) was obtained from lankacidin C-14-C and ethyl propionate by the action of an acylase of the streptomyces.

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