The insulin secretory effect of the human duodenal mucosa.
1970; National Institutes of Health; Volume: 59; Issue: 1 Linguagem: Inglês
Autores
Jean Fasel, H Hadjikhani, J. P. Felber,
Tópico(s)Digestive system and related health
ResumoA study of the mechanism of action of hormonal factors of the intestinal mucosa on insulin release by the pancreas was undertaken by taking biopsies of the duodenal mucosa in 6 normal subjects during the course of an oral glucose tolerance test (100 g per os). Aqueous extracts of these biopsies were injected into the pancreaticoduodenal artery of rats. The injection of the extracts of biopsies removed 30 and 60 min after the glucose load was followed by an important insulin release, whereas the extracts of biopsies taken before and 180 min after glucose load showed only a slight effect on insulin release. The glucose concentration of these extracts was checked and cannot be at the origin of the insulin secretion. This study suggests the formation, in the duodenal mucosa, under the influence of an oral glucose load, of a factor of hormonal character which stimulates the release of insulin by the pancreas. The possibility of the activation of a prohormone or of the rapid synthesis of a hormone is discussed.
Referência(s)