Relaxant Effect of Forskolin in Rabbit Detrusor Smooth Muscle: Role of Cyclic AMP
1986; Lippincott Williams & Wilkins; Volume: 135; Issue: 6 Linguagem: Inglês
10.1016/s0022-5347(17)46077-0
ISSN1527-3792
AutoresTakashi Morita, Marcia A. Wheeler, Robert M. Weiss,
Tópico(s)Pain Mechanisms and Treatments
ResumoNo AccessJournal of Urology1 Jun 1986Relaxant Effect of Forskolin in Rabbit Detrusor Smooth Muscle: Role of Cyclic AMP Takashi Morita, Marcia A. Wheeler, and Robert M. Weiss Takashi MoritaTakashi Morita , Marcia A. WheelerMarcia A. Wheeler , and Robert M. WeissRobert M. Weiss View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)46077-0AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Forskolin caused a concentration dependent relaxation of rabbit detrusor muscle strips. The relaxant effect of forskolin was potentiated by the cyclic AMP sensitive phosphodiesterase inhibitor, Ro20-1274. Pretreatment with the beta-adrenergic antagonist, propranolol, did not inhibit the relaxation of rabbit detrusor induced by forskolin, whereas the relaxation response to forskolin was inhibited in part by the adenylate cyclase inhibitor, SQ22536. Forskolin also increased cyclic AMP levels significantly in rabbit detrusor muscle. These data suggest that detrusor muscle relaxation by forskolin may be mediated by cyclic AMP and that forskolin may activate adenylate cyclase without stimulating beta-adrenergic receptors in detrusor muscle. © 1986 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited ByMorita T, Masuda H, Tosaka A, Ishizaka K, Tsujii T and Kondo S (2018) SEX DIFFERENCES IN FUNCTION AND DISTRIBUTION OF beta-ADRENOCEPTORS IN RABBIT URINARY BLADDERJournal of Urology, VOL. 159, NO. 2, (555-558), Online publication date: 1-Feb-1998.Nishimoto T, Latifpour J, Wheeler M, Yoshida M and Weiss R (2018) Age-dependent Alterations in beta-adrenergic Responsiveness of Rat Detrusor Smooth MuscleJournal of Urology, VOL. 153, NO. 5, (1701-1705), Online publication date: 1-May-1995. Volume 135Issue 6June 1986Page: 1293-1295 Advertisement Copyright & Permissions© 1986 by The American Urological Association Education and Research, Inc.MetricsAuthor Information Takashi Morita More articles by this author Marcia A. Wheeler More articles by this author Robert M. Weiss More articles by this author Expand All Advertisement PDF DownloadLoading ...
Referência(s)